A-4

CA CHL/IU Min ( 0.75 mg/ml, -S9), 24h; D20=0.52, TR=16): ○ 1)

1) Sofuni T. (Ed.): Data Book of Chromosome Aberration Test in vitro, LIC, Tokyo (1998） (Tables in English)

● Aldrin （アルドリン）
　 309-00-2　　Insecticide　　　　364.93　　　　　　　　　　　　

AM Sal Max (5.0 mg/ml; ±S9) □ 1)

YM 　(?) Max (?) □ 2)

CA Human Ly Min（19.1μg/ml,-S9)，22h ○ 3)

UDS Human Fb Min (1.0 μM, +S9) ○ 4)

SCE Rat Min (19.125 μg/kg), ip ○ 3)

1) ?
2) Fahrig R.: IARC. Sci. Pub., 10, 161-181 (1974)
3) Georgian L: Mutation Res., 31, 103-108 (1975)
4) Ahmed FE., et al.:Mutation Res., 42, 161-174 (1977)　

【Note】 (Sited from IARC Monograph, Suppl. 6 (1987)

　No data were available on the genetic and related effects of aldrin in humans.
　It did not induce DL mutation in mice. In single studies, it induced CAs in bone-marrow cells of rats and mice, but no MNs in bone-marrow cells of mice treated in vivo. It induced CAs in cultured human Ly; studies of DNA damage in human and rodent cells in vitro were inconclusive. It inhibited intercellular communication in both human and rodent cell systems. It did not induce SLRL mutations in Drosophila but was mutagenic to yeast. It was not mutagenic to bacteria and did not induce breakage of plasmid DNA,

● Alizarin Red (C1 Pigment Red 83)　（アリザリンレッド）
　 72-48-0　　Insustry/Food　　240.22

AM Sal Min (?) ○ 1)

REC E. coli Min (?) ○ 2)

CA Allium cepa Min (0.5 mM)　 ○ 3)

1) Brown JP., et al: Mutation Res., 56 (3)m 249-272 (1978)
2) Leiger Z., et al.: Mutation Res., 87, 211-297 (1981) (a revies, US NYP)
3) Grant WF: Mutation Res., 99, 273-291 (1982)

● Alkyl-lysophospholipid
　　70641-51-9　　Medicine 523.74

AM Sal Max ( ?, ±S9) □ 1)

CA Hum. Ly. Max ( 0.05 mg/ml, ±S9 ) □ 2)

SCE Hum. Ly. Max ( 0.05 mg/ml, ±S9 ) □ 2)

CAv Hum. Ly. Max ( 516mg/kg in total) □ 2)

1) King MT., et al.,: Cancer Letter, 12, 217-222 (1981)
2) Bauchinger M., et al.: Mutation Res., 121, 225-231 (1983))

● Allethrin 　(アレスリン)
　 584-79-2　　Pesticide　　302.41

AM Sal Min (0.5 mg/plate, +S9) ○ 1)

CA CHL/IU Max ( 0.08 mg/ml, -S9 ), 24h □ 2)

1) Moriya M, et al.: Mutation Res., 116, 185-216 (1983)
2) Sofuni T (Ed.): Data Book of Chromosomal Aberration Test in vitro, LIC, Tokyo (1998） (Tables in English)

● Allspice oil (オールスパイス油) (Pimenta oil)　
　 8006-77-7　　Food/Natural

AM Sal Max (2.0 mg/plate, ±S9) □ 1)

CA CHL/IU Min ( 0.125 mg/ml, -S9 ), D20=0.20 (48h)
○ 2)

MNv Mice Max (?) □ 3)

1) Sekizawa J & Shibamoto T: Mutation Res 101, 127-140 (1982)
2) Sofuni T (Ed.): Data Book of Chromosomal Aberration Test in vitro, LIC, Tokyo (1998) (Tables in English)
3) Hayashi M, et al.: Fd. Chem. Toxicicol., 26, 487-500 (1988)　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
● Allura Red (アルラレッド) (Food Red No.40)　　
　 25956-17-6　　　Food　　　496.42　　　　　　　　　　　

CA CHL/IU Min ( 2.0 mg/ml, -S9 ), 48h ○ 1)

1) Sofuni T.(Ed.): Data Book of Chromosomal Aberration Test in vitro, LIC, Tokyo (1998)

● Allyl alcohol （アリルアルコール; プロペニルアルコール；　2-プロペン-1-オール）
　 107-18-6　 Industrial 　58.08

AM Sal. Min ( 5.8 mg/ml, ±S9) ○ 1)

AM Sal. Max ( 0.05 μl/-plate,±S9 ) □ 2)

AM Sal. Max (?) □ 3)

AM Sal. Max ( 0.2 mg/plate, -S9 ) □ 4)

AM Sal. Min ( 0.3 mg/plate, +S9 ) ○ 5)

MB S. coelicolar Max ( 0.1 ml/plate, ±S9 ) □ 2)

MB A. nidulans Max ( 0.04 ml/plate, ±S9 ) □ 2)

SM V79 Min ( 0.116 mg/l, -S9 ) ○ 6)

CA CHL/IU Min ( 0.006 mg/ml, +S9), 6-18h; D20=0.0062; TR=4100 ◎ 7,8)

1) Lutz D, et al.: Mutation Res., 93, 305-315 (1982) (a review)
2) Principew P., et al., J. Sci., Food. Agric., 32, 826-832 (1981)
3) Rosen JD., et al., Mutation Res., 78, 113-119 (1980)
4) Yamaguchi T., Agric. Biol. Chem., 44, 3017-3018 (1980)
5) Lijinski W & Andrews AW., Terat. Carcinog. Mutagen., 1, 159-267 (1980)
6) Smith RA., et al., Carcinogenesis, 11, 497-498 (1990)
7) Japan Bioassay Reserch Center, Ann Rep. (2005)
8) Ministry of Labour, Japan, Mutagen. Test Data of Exist. Chem. Subst., JETOC (Ed.) Suppl.4, p.176 (2008) (Tables in English)

● Allylbromide　（アリルブロマイド） (3-Bromo-1-propene)
　 106-95-6　　Industrial 　120.98

CA CHL/IU Min (0.03 mg/ml, -S9 ), 24h; D20=0.04 ○ 1)

1) Ministry of Labour, Japan, Mutagen. Test Data of Exist. Chem. Subst., JETOC (Ed.) (1996) (Tables in English)

● Allyl caproate (アリルカプロエイト） (Allyl hexanoate)
　 123-68-2 　　Food 　　156.23　　　　　

CA CHL/IU Max ( 1.0 mg/ml, -S9 ), 48h □ 1)

1) Sofuni T.(Ed.): Data Book of Chromosomal Aberration Test in vitro, LIC, Tokyo (1998) (Tables in English)

AM	Sal	Max (5.0 mg/ml; ±S9)	□	1)
YM	(?)	Max (?)	□	2)
CA	Human Ly	Min（19.1μg/ml,-S9)，22h	○	3)
UDS	Human Fb	Min (1.0 μM, +S9)	○	4)
SCE	Rat	Min (19.125 μg/kg), ip	○	3)

AM	Sal	Min (?)	○	1)
REC	E. coli	Min (?)	○	2)
CA	Allium cepa	Min (0.5 mM)	○	3)

AM	Sal	Max ( ?, ±S9)	□	1)
CA	Hum. Ly.	Max ( 0.05 mg/ml, ±S9 )	□	2)
SCE	Hum. Ly.	Max ( 0.05 mg/ml, ±S9 )	□	2)
CAv	Hum. Ly.	Max ( 516mg/kg in total)	□	2)

AM	Sal	Min (0.5 mg/plate, +S9)	○	1)
CA	CHL/IU	Max ( 0.08 mg/ml, -S9 ), 24h	□	2)

AM	Sal	Max (2.0 mg/plate, ±S9)	□	1)
CA	CHL/IU	Min ( 0.125 mg/ml, -S9 ), D20=0.20 (48h)	○	2)
MNv	Mice	Max (?)	□	3)

AM	Sal.	Min ( 5.8 mg/ml, ±S9)	○	1)
AM	Sal.	Max ( 0.05 μl/-plate,±S9 )	□	2)
AM	Sal.	Max (?)	□	3)
AM	Sal.	Max ( 0.2 mg/plate, -S9 )	□	4)
AM	Sal.	Min ( 0.3 mg/plate, +S9 )	○	5)
MB	S. coelicolar	Max ( 0.1 ml/plate, ±S9 )	□	2)
MB	A. nidulans	Max ( 0.04 ml/plate, ±S9 )	□	2)
SM	V79	Min ( 0.116 mg/l, -S9 )	○	6)
CA	CHL/IU	Min ( 0.006 mg/ml, +S9), 6-18h; D20=0.0062; TR=4100	◎	7,8)