|@No data were available on the genetic and related effects of amitrole
@It did not induce MNs in bone-marrow cells of mice or UDS in hepatocytes of rats treated in vivo. It induced transformation of Sy. hamster embryo cells and increased the
incidence of SCEs in CHO cells; both positive and negative results were
reported for mutation in cultured rodent cells. It did not induce SLRL
mutation or aneuploidy in Drosophila; it induced CAs in plants. Both positive and negative results were obtained
in assays for gene conversion and mutation in fungi, but it induced aneuploidy.
It was not mutagenic to bacteria and did not induce DNA damage. (IARC Monographs,
7, 31, 1974; 41, 293, 1986).