Group B-5 化学構造 (Chemical Structure)  
5'-[bis(2-acetoxyethyl)amino-2'-(2-bromo-4,6-dinitrophenylazo)-4-methoxy-    acetanilide
  
CAS: 3618-72-2  Industry  MW: 625.39
CA CHL/IU Min ( 0.015 mg/ml, -S9), 24h; D20= 0.016
1)
1) Ministry of Labour, Japan; Mutagen. Test Data of Exist. Chemi. Subst.; JETOC (Ed.), (1997) (Tables in English)

● 1,4-Bis (aminoethyl) benzene
  539-48-0  Industry  136.20
AM Sal /E.coli Min (1.25 mg/plate, +S9); Spa= 435 (TA104)
1)
1) Ministry of Labour, Japan; Mutagen. Test Data of Exist. Chemi. Subst.; JETOC (Ed.), (1997) (Tables in English)

● 1,3-Bis(aminomethyl) benzene (1,3-(アミノメチル)ベンゼン) (n-Xylenediamine)
 
1477-55-0  Industry   136.22
AM Sal/E.coli Max ( 5.0 mg/plate, ±S9)
1,2)
CA CHL/IU Max ( 0.47 mg/ml, ±S9). 6-18h
1)
1) Ministry of Health & Welfare,Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 3 (1996)
(Tables in English)
2) Ministry of Labour, Japan; Mutagen. Test Data of Exist. Chemi. Subst.; JETOC (Ed.), (1997) (Tables in English)

● 1,4-Bis(aminopropyl) piperazine
  7209-38-3  Industry   200.33
AM Sal/E.coli Max ( 5.0 mg/plate, ±S9)
1)
1) Ministry of Health & Welfare,Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 3 (1996)(Tables in English)

Bis(1-bromo-2-propenyl) hydrogen phosphate
(ビス(2-ブロモ-2-プロペニル)
  
36596-43-7 Industry   335.92
CA CHL/IU Max ( 4.0 mg/ml, -S9), 24h
1)
1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998)
(Tables in English)
 
1,1-Bis(tert-butyldioxy)-3,3,5-trimethylcyclohexane(1,1-(tert-ブチルジオキシ)-3,3,5-
   トリメチルシクロヘキサン)
   6731-36-8 Industry   302.45
AM Sal/E.coli Max ( 5.0 mg/plate, ±S9)
1)
CA CHL/IU Max ( 3.0 mg/ml, ±S9); 6-18h;
1)
1) Ministry of Health & Welfare,Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 8(2)(2001) (Tables in English)

● Bis(2-chloroethyl) ether  (2,2'-Dichloroethyl ether)
   111-44-4  Industry   143.01
AM Sal/E.coli Min ( 2.5 mg/ plate, -S9);
1)
CA CHL/IU Min( 0.05 mg/ml,+S9), 6-18h; D20= 0.036; TR= 1000
Min( 0.75 mg/ml,-S9), 48h; Poly
2)
HTAv Mice Max ( not specified), or ), for 8 w. 3)
1) Ministry of Labour, Japan: Mutagen. Test Data, Exist. Chem. Subst., Suppl., pp. 149 JETOC (ed.) (1997)(Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998) (Tables in English)

3) Jorgenson A et al., Mutation Res., 53, 124 (1978)
N, N'-Bis(2-chloroethyl)-2-naphthylamin  (Chlornaphazine)(クロロナファジン)
   494-03-1  Industry  268.20
AM Sal Min ( 10.0 μg/plate, +S9)
1)
1) McCann, J. et al.,: Proc. Natl. Acad. Sci.(USA), 72, 5135-5139 (1975)

1,3-Bis (2-chloroethyl)-1-nitrosourea (BCNU) (1,3-ビス(2-クロロエチル)-1-ニトロソ尿素) 
  
154-93-8  Medicine   214.05
AM Sal/E.coli Min (?)
1)
CA CHL/IU Min ( 0.0038 mg/ml, -S9), 24h; D20= 0.003; TR= 7200
2)
1) Ishidate MJr, et al: Natl Inst. of Hygien. Sci., Tokyo (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998) (Tables in English)

Bis(2,3-dibromopropyl) magnesium phosphate (ビス(2,3-ジブロモプロピル)リン酸マグネシウム)
   
36711-31-6  Industry   1017.76
CA CHL/IU Min ( 2.0 mg/ml, -S9), 24h; D20= 3.4; TR= 4.0
1)
1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test in vitro LIC, Tokyo (1998)
(Tables in English)

Bis(dimethylthiocarbamoyl) disulfide (Thiram; TMTD, チラム)
  
137-26-8  Agriculture/Industry   240.44
CA CHL/IU Max ( 0.0004 mg/ml, -S9), 6-18h;
1)
1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998) (Tables in English)

4,4'-Bis(ethylcarbamoyl) diphenylmethane (4,4'-ビス(エチルカルバモイル)ジフェニルエタン)
  Industry   314.38
CA CHL/IU Max ( 0.002 mg/ml, -S9), 6-18h
Min ( 0.0003 mg/ml, -S9), 24h; Poly

1)
1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test in vitro LIC, Tokyo (1998) (Tables in English)

2,4-Bis(ethylcarbamoyl) toluene (2,4-ビス(エチルカルバモイル) トルエン)
 
 Industry   238.28
CA CHL/IU Max ( 0.4 mg/ml, ±S9), 24-48h
1)
1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test in vitro LIC, Tokyo (1998) (Tables in English

5'-[N,N-Bis (2-isobutoxycarbonyl) ethyl]amino]-4'-methoxy-2'-(5-nitro-2-
 thiazolylazo) acetanilide
  82457-22-5  Industry    622.7
CA CHL/IU Min ( 0.013 mg/ml, -S9); 24h; Poly. PD20= 0.024
○p
1)
1) Ministry of Labour, Japan; Mutagen. Test Data of Exist. Chemi. Subst.; JETOC (Ed.), (1996) (Tables in English)
    
● Bis(1-methylethyl)naphthalene (ビス(1-メチルエチル)ナフタレン)

   
38640-62-9   Industry   212.33
AM Sal/E.coli Max ( 5.0 mg/plate, ±S9)
1)
CA CHL/IU Min ( 0.281 mg/ml, +S9); 6-18h; D20= 0.88
1)
1) Ministry of Health & Welfare,Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol.7 (1999)(Tables in English)

Bis(1-methyl-1-phenylethyl) peroxide (過酸化ビス(1-メチル-1-フェニルエチル))
  
80-43-3  Industry   270.37
AM Sal/E.coli Max ( 5.0 mg/plate, ±S9)
1)
CA CHL/IU Max ( 0.02 mg/ml, ±S9); 6-18h;
1)
1) Ministry of Health & Welfare,Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 8(1)(2001)(Tables in English)  

Bisphenol A ビスフェノールA) (2,2-Bis(4-hydroxydiphenyl)proane)
   
80-05-7   Industry   228.29
AM Sal/E.coli Max (.0.625 mg/plate, ±S9) 1)
CA CHL/IU Max ( 0.1 mg/ml, -S9), 6-18h
2)
1) Ministry of Labour, Japan; Mutagen. Test Data of Exist. Chemi. Subst.; JETOC (Ed.), (1996) (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998) (Tables in English)

Bisphenol S ビスフェノールS) (Bis(4-hydroxyphenyl) sulfone)
  
80-09-1   Industry   250.3

AM Sal/E.coli Max ( 5.0 mg/plate, ±S9)
1)
1) Ministry of Labor, Japan; Mutagen. Test Data of Exist. Chemi. Subst.; JETOC (Ed.), (1996) (Tables in English)

● 1,2-Bis(stearoylamino)ethane
 (1,2-ビス(ステアロイル)エタン)
   110-30-5  Industry   593.02
AM Sal /E.coli Max ( 5.0 mg/plate, ±S9)
1)
CA CHL/IU Max ( 0.5 mg/ml, ±S9); 6-18h;
1)
1) Ministry of Health & Welfare,Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 8(1)(2001) (Tables in English)

Bitumens (ビチューメン; 歴青)
  
128683-24-9 Industry

【Note】
(Cited from IARC Monographs, Suppl., 6, 1987)
 Antigenicity against benzo(a)byrene diol epoxide-DNA adducts has been demonstrated in peripheral blood lymphocytes of roofers (1).
 Both an extract of road-surfacing bitumen and its emissions were mutagenic to Salmonella, whereas, in another study, 'asphalt tar' from an asphalt concrete used for road surfacing was not (2).
 Bitumen-based paints for pipe coating were not mutagenic to Salmonella (3).
 1) Shamsuddin, AKM et al., Cancer Res., 45, 66-68 (1985)
 2) Tamakawa, K et al., Sendai-shi Eisei Shikenshoho, 13, 246-257 (1983)
 3) Robinson, M et al., J. Appl. Toxicol., 4, 49-56 (1984)(IARC Monographs, 35, 39, 1985):
Top Page (トップページ)
Abbreviation  (省略記号) 
Mutagenicity (変異原性)
Test Systems (試験法の種類)
Technical Problems (技術的問題点)
List of Compounds(化合物リスト)
Evaluation of Results (試験結果の評価)