Group C-1 化学構造 (Chemical Structure)  
● Cacao pigment (カカオ色素)
   
CAS:   Food MW:
AM Sal . Min (5.0 mg/plate, ±S9) 
w
1)
1) Ishidate MJr.(Ed.): Data Book of Mutagenicity Tests on Chemicals in Bacteria, LIC/Japan (1991) (Tables in English)

Cadmium and compounds (カドミウムと化合物)           
   7440-43-9  Natural/Industry  100.09

CA Human LY Max (?)
1)
CA Human LY Min (?)
2)
1) Bauchinger M., et al.: Mutation Res., 40, 57-62 (1976)
2) O'riordan ML., et al.: Mutation Res., 58, 305-311 (1978)


Note
(Cited from IARC Monograph, Suppl., 6, 1987)
  People exposed occupationally to cadmium (in an alkaline-battery factory and in the manufacture of cadmium pigments) did not exhibit increased frequencies of CAs in their peripheral Lym. These findings contrast markedly with the positive results obtained on workers exposed in zinc smelting plants and on people environmentally intoxicated by cadmium; these people were also exposed to other compounds (see IARC, 11,39; Leonard, 229, 1986). In one study, SCEs were not induced in people exposed to cadmium in the environment (Nogawa, Tsuritani, Yamada, 283, 1986).
  Cadmium compounds did not produce DL effects in mice or rats nor did they increase the frequencies of CAs or MNs in mice treated in vivo. Cadmium compounds induced aneuploidy in hamsters but not in mice treated in vivo. They did not induce SCEs in human cells in vitro, and studies of CAs gave inconclusive results. They induced transformation of cultured rodent cells in several test systems and induced CAs but not SCEs in rodent cells in vitro.
  They induced DNA single-strand breaks in human and rodent cells, and there is conflicting evidence that they produced mutation rodent cells in vitro. They did not induce aneuploidy or somatic or SLRL mutations in Drosophila. They induced mitotic recombination in yeast, but they did not induce mutation in yeast or bacteria, nor did they induce prophage in bacteria.
(IARC Monographs, 2, 74; 11,39)

● Cadmium chloride (2,5 hydrate) (塩化カドニウム)
         7790-78-5  Industry   288.34
AM Sal./E. coli Max ( 5.0 mg/plate±S9)
1)
1) Ministry of Labour, Japan; Mutagen. Test Data of Exist. Chem. Subst., JETOC (Ed.) (1996)  (Tables in English)

● Cadmium nitrate tetrahydrate (硝酸カドミウム四水和物)
   10022-68-1  Medicine   308.48
AM Sal./E. coli Max ( 5.0 mg/plate, ±S9)
1)
CA CHL/IU Min ( 0.012 mg/ml, +S9), 6-18h
1)
1) Ministry of Health, Labour & Welfare, Japan (Ed):Toxicity Testing Reports of Environ. Chemicals, Vol. 9 (2002) (Tables in English)

● Cadmium sulfate (x hydrate)  (硫酸カドニウム)
   15244-35-6  Industry  228.49
AM Sal/E. coli Max ( 5.0 mg/plate, ±S9)
1)
1) Ministry of Labour, Japan; Mutagen. Test Data of Exist. Chem. Subst., JETOC (Ed.) (1996)  (Tables in English)
Caffeine (カフェイン)           
   58-08-2  Food/Natural/Medicine  194.19
REC B. subtilis Min ( 1mg/ml)
1)
AM Sal & E. coli Max (6.0 mg/plate, ±S9) 
2)
MB E. coli / k12 Min ( 1mg/ml)
3)
PLNv Soy bean Min ( 0.1%)
4)
CA CHL/IU Min ( 0.5 mg/ml, -S9), 24h: D20=0.43; TR=35
5)
CA Human/WI-38 Min ( 1300 μM)
6)
CT BHK 21 (Soft agar method); Max(?)
7)
MN Mice/CD Max ( 250 mg/kg x 2), ip
8)
SCE CH Min ( 200 mg/kg x 2) po
9)
DLv Mice/CD Max (120 mg/kg/day)
10)
SPMv Mice Max (200 mg/kg x 5) ip
11)
1) Kada T, et al: Mutation Res., 16, 165 (1972)
2) McCann J, et al: Proc. natl. Acad. Sci. (USA), 72, 5135-5139 (1975)
3) Clarke CH & Wade MJ: Mutation Res., 28, 123-125 (1975)
4) Vig BK: Mutation Res., 31, 49-56 (1975)
5) Ishidate MJr.(Ed): Data Book for Chromosomal Aberration In Vitro, LIC/Tokyo. Elsevier/Amsterdam (1988)
6) Weinstein D, et al: Mutation Res., 46, 297-304 (1977)
7) Styles JA: Brit. J. Cancer, 37, 931-936 (1978)
8) Matter B & Schmid W: Mutation Res., 12, 417-425 (1971)
9) Basler A, et al: Mutation Res., 59, 209-214 (1979)
10) Aeschbacher HU, et al: Mutation Res., 57, 193-200 (1978)
11) Wyrobek AJ & Bruce WR: Proc. Natll Acad. Sci. (USA), 72, 4425-4429 (1975)

● Calciferol (Vitamin D2) (ビタミン D2)      
   50-14-6  Medicine/ Food   396.66

AM Sal. Max ( 5.0 mg/plate, ±S9) 
1)
CA CHL/IU Max ( 0.065 mg/ml, -S9), 24-48h; (No data for +S9)
2)
1) Ishidate MJr. (Ed.): Data Book of Mutagenicity Tests on Chemicals in Bacteria, LIC/Japan (1991) (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998)
(Tables in English)

● Calcimycin (カルシマイシン)    
   52665-69-7 Promotor 523.69

CA CHL/IU Max ( 0.005 mg/ml, -S9), 24-48h; (No data for +S9)
1)
1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998) (Tables in English)

● Calcinated egg shell calcium (焼き卵殻カルシウム)  
    Food/Natural
CA CHL/IU Max ( 0.3 mg/ml, -S9), 24-48h; (No data for +S9)
1)
1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test in vitro LIC, Tokyo (1998)  (Tables in English)

● Calcium alginate (アルギン酸カルシウム   
   9005-35-0      Food
CA CHL/IU Max ( 4.0 mg/ml, -S9), 24-48h; (No data for +S9)
1)
1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998)  (Tables in English)
Calcium carbonate (炭酸カルシウム)
   471-34-1 Food 
100.09
AM Sal. Max ( 50 mg/plate, ±S9) 1)
1) Fujita H. & Sasaki M.: Ann. Rep. Tokyo Metr. Res. Lab. P.H., 38, 423-430 (1987)  (in Japanese)

● Calcium carboxymethyl cellulose
カルボキシセルローズカルシウム
   
9050-04-8  Food  
AM Sal. Max ( 50 mg/plate, ±S9) 1)
CA CHL/IU Max ( 8.0 mg/ml, -S9), 24-48h; (No data for +S9)
2)
1) Ishidate MJr. (Ed.): Data Book of Mutagenicity Tests on Chemicals in Bacteria, LIC/Japan (1991)  (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro,,LIC, Tokyo (1998)
 (Tables in English)

● Calcium chloride (塩化カルシウム)
 
 10043-52-4  Food /Industry/Medicin  70.91
AM Sal. Max ( 5 mg/plate, ±S9)
1, 2)
CA CHL/IU Max ( 4.0 mg/ml, -S9), 24-48h; (No data for +S9)
3)
1) Ishidate MJr. (Ed.): Data Book of Mutagenicity Tests on Chemicals in Bacteria, LIC/Japan (1991)
2) Fujita H. & Sasaki M.: Ann. Rep. Tokyo Metr. Res. Lab. P.H., 38, 423-430 (1987( (in Japanese)
3) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998)  (Tables in English)
● Calcium chromate  (クロム酸カルシウム)
 
 13765-19-0  Industry   156.09
MB E. coli Min ( 0.05 μmol/plate)
1)
AM Sal. Min (?)
2)
CT BHK 21 Min ( 2.5 μg/ml)
3)
1) Venitt S & Levy LS: Nature, 250, 493-495 (1974)
2) Petrilli FL & DeFlora S: Appl. Environ. Microbiol., 33, 805-809 (1977)
3) Fradkin A, et al: Cancer Res., 35, 1058-1063 (1975)

Top Page (トップページ)
Abbreviation  (省略記号) 
Mutagenicity (変異原性)
Test Systems (試験法の種類)
Technical Problems (技術的問題点)
List of Compounds(化合物リスト)
Evaluation of Results (試験結果の評価)