@@@@@@@@@@@
Group C-3 ‰»Šw\‘’@(Chemical Structure)  

œ Calcium stearyl lactylate@iƒXƒeƒAƒƒCƒ‹“ϋŽ_ƒJƒ‹ƒVƒEƒ€j
@@
CAS: 5793-94-2
 
Food@@ MW: 895.68
AM Sal Max ( 0.5 mg/plate, }S9)
 
1)
CA CHL/IU Max ( 0.0625 mg/ml, -S9), 24-48h
 
2)
1) Ishidate MJr (Ed): Data Book for Mutagenicity Test on chemicals in Bacteria, LIC/Tokyo (1991)  (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro,, LIC, Tokyo (1998j   (Tables in English)

œ D -Camphor
(D-ƒJƒ“ƒtƒ‹j
@
464-49-3
@@Medicine @
152.23
AM Sal Max ( 2.5 mg/p‚Œate, }S9)@@
 
1)
CA CHL/IU Max ( 1.0 mg/ml, -S9), 24-48h
 
2)
1) Ishidate MJr (Ed): Data Book for Mutagenicity Tests on Chemicals in Bacteria, LIC/Tokyo (1991)  (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro,, LIC, Tokyo (1998j  (Tables in English)

œ Candelilla wax@i
ƒJƒ“ƒfƒŠƒ‰ƒƒEj
@
8006-44-8
@@Food/Natural@@
AM B. subtilis Max (?)   1)
AM Sal Max (?)@@
 
1)
CA CHL/IU Max ( 5.0 mg/ml, -S9), 24-48h
 
2)
@1) Ishidate, MJr.., et al,: Toxicol. Forum, 11 ,663-669 (1988) (in Japanese)
@2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test I In Vitro, LIC, Tokyo (1998j  (Tables in English)

œ Caprolactam iƒLƒƒƒvƒƒ‰ƒNƒ^ƒ€j(6-ƒwƒLƒTƒ“ƒ‰ƒNƒ^ƒ€;@2-ƒIƒLƒ\ƒwƒLƒTƒƒ`ƒŒƒ“ƒCƒ~ƒ“j
@@
105-60-2
@ @Industrial use/Monomer@@ 113.16
AM Sal. Max (?), }S9@
 
1)
YM Yeast Max (?), }S9@   2)
MB Sal. / Yeast Max (?), }S9@   2)
SM CHO Max (?), }S9@   2)
SM V79 Max (?), }S9@@   2)
SM Balb/c3T3 Max ( 15 mg/ml), +S9@ ’ 2)
SM Human lym. Max ( 8 mg/ml), }S9@@@   2)
AM L5178Y Max (?), }S9@@@   2)
CA CHL/IU Max ( 0.27 mg/ml, }S9), 6-18h
’
3)
CA Human LY Min ( 0.75 mg/ml, }S9), 3-25h
›w
2)
CA CHO Max ( 5 mg/ml,), }S9)
 
2)
SCE CHO Max ( 5 mg/ml), }S9)@   2)
SCE Rat, RL4 Max (?), -S9@   2)
SCE Human lym. Max ( 1 mg/ml), -S9@   2)
UDS Rat hepatocytes Max (?), -S9   2)
MCo V79 Max (?), -S9   2)
CT Balb/c3T3 Min ( 7.5 mg/ml), +S9, for 48h ›w 2)
CT C3H 10T 1/2 Min (?), 4.5 mg/ml), -S9
›w
2)
CT Syr. ham. Min ( 0.1 mg/ml), -S9, for 7d ›w 2)
CT Rat RLV Max (?), -S9,   2)
SMv Drosophila Min ( 91 mg/ml), for 6h ›w 2)
SLRLv Drosophila Max (?)   4)
SMv Mice, spot-test Min ( 700 mg/kg) ’ 5)
MNv Mice, BM Max (?)   5)
DNAv Rat hepatocytes Max (?)   6)
UDSv Rat hepatocytes Max (?)   5)
SCEv Mice, BM Max (?)   5)
CAv Mice, BM Max (?)   5)
SPAv Mice, sperms Max (?)   5)
‚PjGreene EJ., et al.: Environ. Mutagen., 1, 399-407 (1979)
2) IPCS, Collaborative Studies; In Ashby J., et al. (eds), Prog. Mutation Res. Vol. 5 (1985)
3) Ishidate MJr.(Ed.): Data Book, Chromosomal Aberration Test n Vitro, LIC, Tokyo/Elsevier, Amsterdam (1988)
4) Foureman P., et al., Environ. Mol. Mutagen., 23, 51-63 (1994)
5) Special Issue, Mutation Res., 224 (1989)
6) Kitehin KT & Brown JL, Teratog. Carcinog. Mutag., 9, 273-285 (1989)

US-NTP Genotoxicity ScreeningF
 ›@Ames TestF@ 

 ›@Mouse Lymphoma Test F@ 
 ›@CA Test with CHO CellsF@ 
 ›@
SCE Test with CHO CellsF@ 
. ›@SLRL Test with DrosophilaF@ 

œ ƒΓ-Caprolactone@iƒΓ-ƒJƒvƒƒ‰ƒNƒgƒ“j
@@ 502-44-3
@@Laboratory@ 114.14
AM Sal. Max (?)
 
1)
CA CHL/IU Max (1.0 mg/ml, -S9), 24-48h
 
2)
1) (?)
2) Sofuni T. (Ed.): Data Book of Chromosome Aberration Test In Vitro, LIC, Tokyo (1998j  (Tables in English)

œ Capsanthin (
Karamigen A)
@@
465-42-9@Food@ 584.88
AM Sal. Max ( 10.0 mg/plate, }S9)
 
1)
CA CHL/IU Max ( 2.0 mg/ml, -S9),  24-48h
 
2)
1) Ishidate MJr (Ed): Data Book for Mutagenicity Test in Bacteria, LIC/Tokyo (1991)
2) Sofuni T. (Ed.): Data Book of Chromosome Aberration Test In Vitro, LIC, Tokyo (1998j  (Tables in English)

œ Capsicum oil
@(Paprika oil, ƒpƒvƒŠƒJ–ϋj
@ @@@@@@Food/Natural@
AM Sal Max (?)@
 
1)
CA CHL/IU Max (1.0 mg/ml, -S9), 24-48h
 
2)
1) Ishidate MJr, et al: Fd. Chem. Toxicol. , 22, 623-636 (1984)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998j  (Tables in English)

œ@Captafol@iƒLƒƒƒvƒ^ƒz[ƒ‹j @
@@@
@ 2425-06-1@ Fungicide@ 349.06
MB E. coli Min( 0.15 ƒΚmol)
›
1)
AM Sal. Max( 0.2 mg/plate)
 
2)
CA CHL/IU Min( 0.004 mg/ml, -S9), 3-21h
›
3)
CA V79 Min( 0.014 mg/ml, -S9), 27h
›
4)
DLv Mice Max( 3.0 mg/kg, ip)
 
5)
‚Pj Morita M., et al.: Mutation Res., 57, 259 (1978)
2)@Carere A., et al.: Mtation Res., 57, 277-286 (1978)
3)@Ishidate MJr.(Ed.): Data Book, Chromosomal Aberration Test In Vitro, LIC, Tokyo/Elsevier, Amsterdam (1988)
4)@Tezuka H., et al.: Mutation Res., 78, 177-191 (1980)
5)@Kennedy GL., et al.: Fd. Cosmet. Toxicol., 13, 55-61(1975)

œ@Captan @iƒLƒƒƒvƒ^ƒ“j

@@@
@133-06-2@Fungicide@@ 300.59
AM Sal Min( 10 ƒΚg/ml)
›
1-5)
YM S. cerevcisiae
A. nidulans
Min( 0.2 mg/plate)
›
6, 7)
HMA Sal/Rats Max( 2.0 g/kg, po)
 
8)
SLRLv Drosophila Min (?)
›
9, 10)
CA Bicia faba Min ( 10 ppm), 4-22h
›
11)
SM V79/Ouabain Min( 10 ƒΚg/ml)@@
›
12)
SM CHO/HGPRT Min( 0.25ƒΚg/ml, -S9)
›
13)
CA CHL/IU Min ( 0.007 mg/ml, -S9), 24h; D20:= 0.014; TR= 1000

14)
SCE Hum LY Min ( 10-5 M)
›
15)
SCE Hum Fb Max ( 0.004 mg/ml)
 
16)
MLA L5178Y Min ( 0.06 ƒΚg/ml, -S9) › 21)
UDS Hum Fb Min ( 1.0 ƒΚM, +S9)
›
17)
CAv Rat/BM Max ( 200 mg/kg)
 
16)
MNv Mice/BM Min ( 100 mg/kg)
›
18)
DLv Mice Min ( 3-6 mg/kg)
›
19)
DLv Rats Min ( 200 mg/kg/day x 5)
›
16)
Other Chromotest Min ( 0.1 ƒΚg/ml, -S9)
›
20)
1) Bridges BA: Mutation Res., 32, 3-34 (1975)
2) McCann J., et al.: Pro. Natl Acad. Sci. (USA), 72, 979-983 (1975)
3) Shirasu Y, et al: Mutation Res., 40, 19-30 (1976)
4) Saxena S, et al: Biochem. Mol. Bio. Inst., 41, 1125-1136 (1997)
5) Carere A, et al: Mutation Res., 57, 277-286 (1978)
6) Siebert D., et al.: Mutation Res., 10, 533-543 (1970)
7) de Bertoldi M, et al: Environ. Mutagen., 2, 359-370 (1980)
8) Ficsor G, et al: Mutation Res., 48, 1-15 (1977)
9) Mollet P.: Mutation Res., 21, 137-138 (1973)
10) Kramers PC & Knaap AG: Mutation Res., 21, 149-154 (1973)
11) deKergommeaux DJ, et al: Mutation Res., 124-69-84 (1983)
12) Arlett CF., et al.: Mutation Res., 33, 261-278 (1975)
13) O'Neill, JP, et al: Environ. Mutagen., 3, 233-237 (1981)
14) Ishidate MJr.(Ed.): Data Book, Chromosomal Aberration Test In Vitro, LIC, Tokyo/Elsevier,@Amsterdam (1988)@@@
15) Vigfusson NV & Vyse ER: Mutaton Res., 79, 53-57 (1980)
16) Tezuka H., et al.: Mutation Res., 57, 201-207 (1978)
17) Ahmed FE., et al.: Mutation Res.,42, 161-174 (1977)
18) Feng JY & Lin BY: Environ. Res., 3, 359-363 (1987)
19) Kennedy GL., et al.: Fd Cosmet. Toxicol., 13, 55-61 (1975)
20) Rniz MJ & Marzin D: Mutation Res., 390, 245-255 (1997)
21) Oberly TJ., et al., Mutation Res., 125, 291-306 (1984)

US-NTP Genotoxicity ScreeningF
› Ames Test (}S9):
@›
› CA Test with CHO Cells:@›@
› SCE Test with CHO Cells: @
›

IARC Carcinogenicity CriteriaF
Group 3 @
(Not classifiable as to its carcinogenicity in humans)

œ Caramel
iƒJƒ‰ƒƒ‹j

@
8028-89-5@@@Natural/Food
AM Sal Min ( 50 mg/plate, -S9)
›w
1)
CA CHL/IU Min ( 8.0 mg/ml, -S9), 24-48h; D20= 9.2; TR= 2.4
›w
2)
1) Ishidate MJr, et al: Fd. Chem. Toxic. , 22, 623-636 (1984)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998j  (Tables in English)

œTop Page@iƒgƒbƒvƒy[ƒWj
œAbbreviation @iΘ—ͺ‹L†j@
œMutagenicity@i•ΟˆΩŒ΄«j
œTest Systems@(ŽŽŒ±–@‚ΜŽν—ށj
œTechnical Problems@i‹Zp“I–β‘θ“_j
œList of@Compoundsi‰»‡•¨ƒŠƒXƒgj
œEvaluation of Results@iŽŽŒ±Œ‹‰Κ‚Μ•]‰Ώj