●Daunamycin　（ドウナマイシン） (Daunorubicin, Rubidomycin)
　　　20830-81-3　Medicine　 543.53

AM	Sal.	Min ( 6 μg/Plate, -S9)	○	1)
CA	Human LY	Min ( 0.02 μg/ml, -S9)	○	2)
SCE	Human LY	Min ( 0.003 μg/ml, -S9)	◎	2)
CAv	Rat/BM	Min ( 5 mg/kg)	○	3)

1) McCann J., et al., Proc. Natl. Acad. Sci. (USA), 72, 5135-5139 (1975)
2) Shiraishi Y & Sandberg AA., Natl. Cancer Inst., 62, 27-35 (1979)
3) Jensen MK & Philip P., Mutation Res., 12, 91-96 (1971)

● Dazomet 　(Basamid MG, Gasturd MG)（ダゾメット）
　　    533-74-4　　Pesticide　 162.3

REC	B. subtilis	Max ( 10 mg/plate)	□	1)
AM	Sal./E. coli	Max ( 0.2 mg/plate), ±S9	□	1)
CA	Human LY	Max ( 0.025 mg/ml), +S9	□	1)

 1) BASF Japan, Co., Ltd.: J. Pesticide Sci., 17, S527-S335 (1992)

● D & C Red No. 7
　　　 5281-04-9　　Pesticide　 162.3

AM	Sal./E..coli	Max ( 5.0 mg/plate, ±S9)	□	1)
CA	CHL/IU	Max ( 5.0 mg/ml, ±S9) 6-12h	□	1)

1) Ministry of Health & Welfare, Japn: Tox. Test. Rep. of Environ. Chem., Vol. 2, 199 (1995) (Tables in English)

● DDT　（Dichlorodiphenyltrichloroethane ；Agritan）　
　　　 50-29-3　　Insecticide (No use) 354.49
　　　　
US-NTP Genotoxicity Screening:
○　Ames Test:　　□
○　Genotoxicity Tests with Drosophila :□
○　CA Test with CHO Cells:　□
○　SCE Test with CHO Cells:　□
　　　
IARC Criteria for Cacrinogenicity:
   Group 2B 　(Probably carcinogenic in humans)　　　

  【Note】 (Cited from IARC Monographs Suppl., 6 (1987)

In a single study, it was reported that workers exposed to DDT and other pesticides showed increases in chromatid-type aberrations, but not in chromosomal aberrations, in peripheral lymphocytes. 　　Conflicting results were obtained for the induction of DL mutations in mice and rats. It induced CAs in bone-marrow cells of mice, but not of rats, and CAs in spermatocytes of mice treated in vivo; it did not induce MNs in bone-marrow cells of treated mice. In human cells in vitro, it did not induce CAs, mutation or UDS. It did not induce mutation, DNA strand breaks or UDS in cultured rodent cells; It inhibited intercellular communication in human and rodent cell systems. It did not induce SLRL mutations in Drosophila, but conflicting results were obtained with regard to aneuploidy; it cause DL mutations. It did not induce mutation in fungi, bacteria and did not induce breakage of plasmid DNA. (IARC Monographs, 5, 83)

● Debromoaplysiatoxin　（デブロモアプィリシアトキシン）
　　　  52423.28-6      Labouratory/Promotor 　592.73

CA

CHL/IU

Max ( 0.0025 mg/ml, -S9), 24-48h　(No data for +S9)

□

1)

1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998) (Tables in English)

● Decabromodiphenyl ether (デカプロモフェニルエーテル;　ビス（ペンタブロモフェニル）エーテル）
　　　 1163-19-5　Industry　959.17

AM	Sal./E. coli	Max ( 10.0 mg/plate, ±S9)	□	1,2)
AM	Sal.	Min ( 5.0 mg/plate, ±S9)	○	3)
CT	Syr.Ham,	Max ( 0.025 mg/ml, ±S9)	□	4)
CA	CHO	Max ( 0.5 mg/ml, ±S9)	□	2)
MLA	L5178Y	Max ( 0.01 mg/ml, ±S9)	□	5)
SCE	CHO	Max ( 0.5 mg/ml, ±S9)	□	2)
MNv	Mice, BM	Max ( 0.1 g/kg, or )	□	6)

1) Ministry of Labour, Japan: Mutagenicity Test Data of Exist. Chem. Subst., Suppl. 2 (2000) (Tables in English)
2) US-NTP, Tech. Rep. No,309 (1986)
3) BFRIP, Huntington Res.,EPA DOC.LD, 86-900000367, OTS0522930 (1984)
4) LeBoeuf RA et al., Mutation Res., 356, 85-127 (1996)
5) McGregor DB et al., Environ. Mol. Mutagen, 12, 85-154 (1988)
6) Norris JM., et al.., Environ. Health Perspect., 11, 153-161 (1975)

Carcinogenicity Criteria: IARC:
Group 3　(not classified to be carcinogenic in humans)　

● 1-Decanol (n-Dcyl alcohol)
　　　112-30-1　Industry　158.28

AM

Sal./E. coli

Max ( 0.0781 mg/plate, ±S9)

□

1)

1) Ministry of Labour, Japan: Mutagenicity Test Data of Exist. Chem. Subst., Suppl. 2 (2000) (Tables in English)

● Decyl aldehyde 　(1-Decanal)　（デシルアルデヒド）
　　　 112-31-2　Food　156.27

AM	Sal.	Max (?)	□	1)
CA	CHL/IU	Max ( 0.125 mg/ml,-S9), 24-48h　(No data for +S)	□	1)

1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998) (Tables in English)

● Dehydroacetic acid　（DHA)　　 （デヒドロ酢酸）　
　　　 520-45-6　Food/Industry　 168.16　　

AM	Sal.	Max ( 5.0 mg/plate, ±S9),	□	1)
CA	CHL/IU	Max ( 0.25 mg/ml, -S9), 24-48h 　(No data for +S9)	□	2)

1) Ishidate MJr. (Ed.), Data Book of Mutagenicity Tests on Chemicals in Bacteria, LIC/Tokyo (1991) (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro,, LIC, Tokyo (1998) (Tables in English)

● Diacetone alcohol   （ジアセトンアルコール）
　　　 123-42-2 　Industry　　 116.18

AM	Sal./E. coli	Max ( 5.0/plate, ±S9)	□	1)
CA	CHL/IU	Max ( 1.2 mg/ml, ±S9)	□	1)

1) Ministry of Health & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol.　5 (1997) (Tables in English)

● Diallyldimethylammonium chloride　（ジアリルメチルアンモニウムクロライド）　　　 　　
　　　 7398-69-8 　Industry　　 161.68

AM

Sal./E. coli

Max ( 5.0/plate, ±S9)

□

1)

1) Ministry of Labour, Japan: Mutagenicity Test Data of Exist. Chem. Subst., Suppl. 2 (2000) (in Japanese) (Tables in English)

● Diallylphthalate (Phthalic acid, diallyl ether)　（ジアリルフタレート）　　　 　　
　　　 131-17-9　Industry　　 246.26

AM

Sal./E. coli

Max ( 5.0/plate, ±S9)

□

1)

1) Ministry of Labour, Japan: Mutagenicity Test Data of Exist. Chem. Subst., Suppl. 2 (2000) (Tables in English)

● 2,4-Diaminoanisole sulfate 　（2,4-ジアミノアニソール・硫酸）　　　 　　
　　　 39156-41-7 　Dye/Industry　　 285.21

AM	Sal	Min (?)	○	1)
CA	CHL/IU	Min ( 0.06 mg/ml, -S9), 24h: D20= 0.04; TR= 270	○	2)

1) Natl. Inst. Hygien. Sci., Tokyo ?
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro,, LIC, Tokyo (1998） (Tables in English)

● 1,4-Diaminoanthraquinone （1,4-ジアミノアントラキノン）　　　
　　　　 128-95-0　Industry　238.25　

AM	Sal.	Min ( 0.153 μg/plate, +S9), spa = 562000 (TA98)	◎	1)
CA	CHL/IU	Min ( 0.25 mg/ml, -S9), 24h: D20= 0.55; TR= 12	○	2)
CA	CHL/IU	Min ( 0.08 mg/ml, -S9), 24h: D20= 0.086;	○	1)

1) Ministry of Labour, Japan, Mutagenicity Test Data of Exist. Chem. Subst., JETOC (Ed.) (1996) (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro,, LIC, Tokyo (1998） (Tables in English)

● 4,4'-Diaminobenzanilide （4,4'-ジアミノベンツアニリド）
　　　　 785-30-85　Industry　 227.27

AM

Sal./E. coli

Max ( 5.0/plate, ±S9)

□

1)

1) Ministry of Labour, Japan: Mutagenicity Test Data of Exist. Chem. (1996) (Tables in English)

● 3,5-Diaminobenzoic acid （3，5-ジアミノ安息香酸）
　　　　 535-87-5　Industry　 152.14

CA	CHL/IU	Max (3.0 mg/ml,±S9), 6-18h	□	1)
CA	CHL/IU	Min (3.0 mg/ml,-S9), 24h; D20= 0.086	○	2)

1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test in vitro, LIC, Tokyo (1998） (Tables in English)
2) Ministry of Labour, Japan, Mutagenicity Test Data of Exist. Chem. Subst., JETOC (Ed.) (1996) (Tables in English)

● 3,4-Diaminochlorobenzene （3,4-ジアミノクロロベンゼン）
　　　　 95-83--0　Industry　 142.6

CA

CHL/IU

Min ( 0.005 mg/ml, -S9), 48h; D20= 0.004　(No data for +S9)

◎

1)

1) Ministry of Labour, Japan, Mutagenicity Test Data of Exist. Chem. Subst., JETOC (Ed.) (1996) (Tables in English)

● Diaminodiphenyl ether （Bis(4-aminophenyl)ether, DADPE）
　　　　 101-80-4　Industry　 200.24

AM	Sal./E. coli	Min (39.1 μg/plate, +S9), spa = 11300	◎	1)
CA	CHL/IU	Min (0.078 mg/ml, -S9), 24h: D20= 0.03	○	1)

1) Ministry of Labour, Japan, Mutagenicity Test Data of Exist. Chem. Subst., JETOC (Ed.), Suppl (1997) (in Japanese)

● 2,4-Diamino-6-methyl-1,3,5-triazine (Acetoguanamine)
　　　　 542-02-9　Industry　 125.13

AM

Sal./E. coli

Max ( 5.0mg/plate, ±S9)

□

1)

1) Ministry of Labour, Japan: Mutagenicity Test Data of Exist. Chem. (1996) (Tables in English)

● 2,6-Diaminopyridine (2,6-Pyridinediamine)　（2,6-ジアミノピリジン）
　　　　 141-86-6　Industry　 109.13

AM

Sal/E. coli

Max (1250 μg/plate, +S9), spa = 14.4 (TA1537)

○

1)

1) Ministry of Labour, Japan, Mutagenicity Test Data of Exist. Chem. Subst., JETOC (Ed.), Suppl. (1997) (in Japanese)

● 4,4-Diaminostilbene-2,2'-disulfonic acid
　　　　 81-11-8　Industry　 370.41

AM

Sal./E. coli

Max (10 mg/plate, ±S9)

□

1)

1) Ministry of Labour, Japan, Mutagenicity Test Data of Exist. Chem. Subst., JETOC (Ed.), Suppl. 2 (2000) (Tables in English)

● 2,4-Diaminotoluene （2，4-ジアミノトルエン） (1,3-Amino-4-methylbenzene); 2,4-Toluenediamine)
　　　　 95-80-7　Industry　 122.17

AM	Sal./E. coli	Min (78.1μg/plate, +S9), spa= 633 (TA98)	○	1)
AM	Sal.	Min (100 μg/plate, +S9)	○	2)
AM	Sal.	Min (1 mg/plate, +S9)	○	3)
AM	Sal.	Min (3.3 mg/plate, +S9)	○	4)
CA	CHL/IU	Min (0.013 mg/ml, -S9), 48h; D20= 0.013	◎	1)
CA	CHO	Min (4.9 mg/ml, ±S9)	○	5)
SM	CHO	Min (6 mg/ml, ±S9)	○	6)
SCE	CHO	Min (4.68 mg/ml, ±S9)	○	5)
MLA	L5178Y	Min (1 mg/ml, -S9)	○	6)
DNA	Calf thymus	Min (2 mg/ml, +S9)	○	7)
UDS	Rat hepatocytes	Min (0.1 mg/ml)	○	10)
CT	Sy. ham.	Min (0.05 mg/ml, -S9)	○	11)
MNv	Rats, BM	Max (150 mg/kg), or	□	4)
DLv	Mice	Max (40 mg/kg/d), for 2 days, ip /or	□	8)
UDSv	Rats, liver	Max (300 mg/kg), or	△	4)
DNAv	Rats, liver	Min (180 ppm), fed	○	9)

1) Ministry of Labour, Japan, Mutagenicity Test Data of Exist. Chem. Subst., JETOC (Ed.), (1996) (Tables in English)
2) Hirayama A., et al., EISEIGAGU, Japan, 31, 113, 118 (1985)
3) Furlong BB et al., Carcinogenesis, 8, 247-251 (1987)
4) George E & Westmoreland C, Carcinogenesis, 17, 2233-2237 (1991)
5) Loveday KS., et al., Environ. Mol. Mutagen., 16, 272-303 (1990)
6) Coppinger., et al., Mutation Res., 135, 115-123 (1984)
7) Citro G., et al., Xenobiotica, 23, 317-125 (1993)
8) Soares ER & Lock LF., Enveron. Mutagen., 2, 111-124 (1980)
9) Declos KB., et al., Mutation Res., 367, 209-218 (1996)
10) BUA Report, 192 (1995)
11)Hazardous Substances Data Bank (HSDB), U.S. Natl  Library of Medicine (1998)

 【Note】
Carcinogenicity Criteria: IARC:
Group 2B 　(Probably carcinogenic in humans)　

● 1,10-Diazachrysene  (1，10-DAC)
　　　　218-21-3　Industry　 230.27

AM

Sal.

Min (＜5.0 nmol/plate / +HS9)

○

1)

1) Yamada K., et al., Mutation Res., 586, 87-95 (2005)

● Diazepam （ジアゼパム）
　　 439-14-5　Medicine　 284.74

AM	Sal..	Max ( 1.0 mg/plate, ±S9)	□	1)
CA	CHL/IU	Max ( 0.125 mg/ml, -S9), 24-48h: Max ( 1.0 mg/ml, +S9), 3-21h:	□ △	2, 3)
CA	Human LY	Max ( 0.05 mg/ml, -S9)	□	4)
CA	CH/BM	Max ( 900 mg/kg x 10), po	□	5)

1) Waskell LA: Mutation Res., 57, 141 (1978)
2 ) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro,, LIC, Tokyo (1998） (Tables in English)
3) Matsuoka A, et al,: Mutation Res., 66, 277-290 (1979)
4) Staiger GR: Mutation Res., 10, 635-644 (1970)
5) ( ?)

【Note】　(Cited from IARC Monographs Suppl., 6 (1987)

Neither CAs nor SCEs (one study) were observed in the lymphocytes of patients receiving treatment with diazepam. 　　Diazepam did not induce CAs in bone-marrow cells of Chinese hamsters treated in vivo, or in human or Chinese hamster cells in vitro. It did not inhibit intercellular communication in cultured rat hepatocytes. It was not mutagenic to bacteria, but urine from mice treated with this agent showed increased mutagenicity as compared to controls. (IARC Monographs, 13, 57)

● Diazinon （ダイアジノン）
　　　 333-41-5　　Pesticide　 304.34

REC	B. subtilis	Max ( 0.1 mg/disk),	□	1)
AM	Sal./E. coli	Max ( 5.0 mg/plate),	□	1)
YM	S. serev.	Max (?)	□	2)
CA	CHL/IU	Max ( 0.125 mg/ml, -S9), 24-48h Min ( 0.1mg/ml, +S9), 3-21h:	□ ○	3) 4)
CA	Human LY	Max ( 0,02 mg/ml, -S9)Max ( 0.02 mg/ml, +S9)	□ △	1)
CA	Human LY	(Intoxication) Max (?)	○	5)

1) Nihon Kayaku Co., Ltd.,: J. Pesticide Sci., 14, 113-118 (1989)
2) Fahrig R: IARC. Sci. Pub., 10, 161-181 (1974)
3) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro,, LIC, Tokyo (1998） (Tables in English)
4) Matsuoka A, et al,: Mutation Res., 66, 277-290 (1979)
5) Van Bao T, et al,: Humangenetik, 24, 33-57 (1974)

●Top Page　（トップページ）

●Abbreviation 　（省略記号）

●Mutagenicity （変異原性）

●Test Systems　(試験法の種類）

●Technical Problems　（技術的問題点）

●List of　Compounds （化合物リスト）

●Evaluation of Results　（試験結果の評価）