@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@
Group D-5 ‰»Šw\‘’@(Chemical Structure)  
œ Dichloromethane iƒWƒNƒƒƒƒ^ƒ“j
@@@@CASF75-09-2@Industry@ MW: 84.93
AM Sal. Min ( 1.0 mg/plate, }‚r9) ;@spa=1.9
›w
1)
CA CHL/IU Max ( 8.0 mg/ml, }M‚r9), 6-18h
 
2)
MN Mice (CD-1) Max ( 1720 mg/kg, ip)   3)
‚PjIshidate MJr (Ed): Data Book for Mutagenicity in Bacteria, LIC/Tokyo (1991) (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998)   (Tables in English)
3) Morita T. et al., Mutation Res., 329, 3-122 (1997)

yNotez
@iCited from IARC Monographs Suppl., 6, 1987)
@@No data were available on the genetic and related effects of this compound in humans.
@@It did not induce CAs in bone-marrow cells of rats or MNs in mice treated in vivo. UDS was not induced in human cells in vitro. It induced transformation of virus-infected Fischer rat and Syrian hamster embryo cells. It induced CAs, but not mutation or DNA damage, in rodent cells in vitro; conflicting results were reported for the induction of SCEs in Chinese hamster cells. It induced SLRL mutations in Drosophila. It mutagenic to plants and induced mutaion, mitotic recombination and gene conversion in Saccharomyces cerevisiae under conditions in which endogenous levels of cytochrome P450 were enhanced. It was mutagenic to bacteria. (IARC Monographs, 20, 449; 41, 43)

      œ 2,4-Dichloro-1-methylbenzene i2,4-ƒWƒNƒƒ-1-ƒƒ`ƒ‹ƒxƒ“ƒ[ƒ“j
@@@@       95-73-8@Industry@ 161.03
AM Sal../E. coli Max ( 1.0 mg/Plate, }‚r9;
 
1)
CA CHL/IU Max ( 0.09 mg/ml, }‚r9), 6-18h
 
1)
‚Pj Chem. Invest. Promot. Com.:@Toxi.Test. Rep. of Environ. Chem., Vol. 1 (1994)

œ
2,3-Dichloro-1,4-naphthoquinone +
        117-80-6@Industry@ 227.05
AM Sal./E. coli Max ( 5 mg/p;ate, }S9)
 
1)
1) Ministry of Labor, Japan: Mutagenicity Test Data of Exist. Chem. Subst. JETOC (Ed.), p.104 (1996) (Tables in English)

œ 1,2-Dichloro-3-nitrobenzene i‚PC‚Q|ƒWƒNƒƒ|‚R|ƒjƒgƒƒxƒ“ƒ[ƒ“j
@@@@ 3209-22-1@Industry@ 192.00
CA CHL/IU Min ( 0.12 mg/ml, -‚r9), 48h; (Also poly.)
›w
2)
‚Pj Chem. Invest. Promot. Com.:@Toxi.Test. Rep. of Environ. Chem., Vol. 1 (1994)

œ 1,2-Dichloro-4-nitrobenzene i‚PC‚Q-ƒWƒNƒƒ-4-ƒjƒgƒƒxƒ“ƒ[ƒ“j
@@@@99-54-7@  Industry@  192.00
AM Sal../E. coli Min ( 0.0195 mg/plate, +‚r9) spa=1.1 x 104

1)
CA CHL/IU Min ( 0.08 mg/ml, +S9), 6-18h; D20= 0.085; TR= 220  2)
1) Ministry of Labour, Japan: Mutagenicity Test Data of Exist. Chem. Subst. JETOC (Ed.), Suppl. 3, pp. 140 (2005) (Tables in English)
2) Ministry of Labour, Japan: Mutagenicity Test Data of Exist. Chem. Subst. JETOC (Ed.), Suppl. 3, pp. 230 (2005) (Tables in English)

œ 1,4-Dichloro-2-nitrobenzene i‚PC‚S-ƒWƒNƒƒ-‚Q-ƒjƒgƒƒxƒ“ƒ[ƒ“ƒ“j
@@@@89-61-2@Industry@ 192.00
AM Sal. Min ( 0.07813 mg/plate, -‚r9)
›
1, 10)
AM Sal./E. coli Min ( 0.07813 mg/plate, -‚r9) › 2)
CA CHL/IU Min ( 0.094 mg/ml, +‚r9)
›
1)
CA CHL/IU Min ( 0.094 mg/ml, +‚r9) › 3)
AM Sal. Min ( 1.6 mg/plate, -‚r9) › 4)
AM Sal. Max( 5 mg/plate, }‚r9)   5)
SM V79 Max ( 0.25 mg/ml, }‚r9)   6)
CA CHL/IU Max ( 0.094 mg/ml, }‚r9)   7)
UM Sal. Min ( 1 mg/ml,  -‚r9), 2h › 8)
UM Sal. Max ( 0.01 mg/ml, }‚r9), 4h   9)
‚Pj Chem. Invest. Promot. Com.:@Toxi. Test. Rep. of Environ. Chem., Vol. 3 (1996)@
2) Ministry of Labour, Japan: Mutagenicity Test Data of Exist. Chem. Subst. JETOC (Ed.), pp. 181 (1996) (Tables in English)
3) Ministry of Labor, Japan: Mutagenicity Test Data of Exist. Chem. Subst. JETOC (Ed.), pp. 452 (1996) (Tables in English)
4) Shimizu M., et al., Mutation Res., 116, 217-238 (1983)
5) Kawai A., et al., Jpn j. Indust. Health., 29., 34-54 (1987)
6) Muller W., Bericht Nr. 89.0824, Hoechst A4 Frankfurt (Main), 1-23 (1989)
7) Kusakabe H., et al, Hatano Res. Inst. (Kanagawa, Japan), 2402 (2002)
8) Jin ZC & Qian J., Mutation Res., 264, 1-5 (1991)
9) Ono Y., et al., Water Sci. Technol., 26, 61-69 (1992)
10) Registry of Toxic Effects of Chemical Substances (RTECS), US NIOSH (1996)

œ 2,4-Dichloronitrobenzene i‚QC‚S-ƒWƒNƒƒƒjƒgƒƒxƒ“ƒ[ƒ“j
@@@@611-06-3@Industry@ 192.00
CA CHL/IU Max ( 0.14 mg/ml, }‚r9), 6-18h
 
1 2)
‚Pj Chem. Invest. Promot. Com.:@Toxi.Test. Rep. of Environ. Chem., Vol. 3 (1996)
@@
œ 1,1-Dichloro-1-nitroethane i1,1-ƒWƒNƒƒ-1-ƒjƒgƒƒGƒ^ƒ“j
@@@ 594-72-9@ Industry 143.96

   US-NTP Genotoxicity ScreeningF
  ›@Ames Test: (}S9)F@
›

œ 2,4-Dichlorophenol i‚QC‚S-ƒWƒNƒƒƒtƒFƒm[ƒ‹j@
@@@120-83-2@Medicine@@ 163.00
CA CHL/IU Max ( 0.4 mg/ml, -S9), 6-18h (with slight Poly.)
’
1)
‚Pj Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998)   (Tables in English)

yNotez
@iCited from IARC Monographs Suppl., 6, 1987)
@@No data were available on the genetic and related effects of this compound in humans.
@@It did not induce UDS in rat hepatocytes in vitro or mutation in bacteria. (IARC Monographs, Suppl. 4, 88; 41, 319)

      œ (2,4-Dichlorophenoxy) acetic acid@(2,4-D)
@@        @ 94-75-7@Agriculture@ 221.04
CA CHL/IU Max ( 5.0 mg/ml, }S9), 6-18h
 
1)
‚Pj Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998) (Tables in English)

yNotez@iCited from IARC Monographs Suppl., 6, 1987)
@@In single studies, lymphocytes of persons occupationally exposed to this chlorophenoxy herbicides, including 2,4-D, did not show increased frequencies of SCEs or CAs. Other studies could not be assessed since workers were also exposed to other formulations.
@@2,4-D did not induce DL mutations, MNs or SCEs in rodents treated in vivo. Pure 2,4-D did not induce CAs in human lymphocytes in vitro, whereas a commercial formulation did (Mustonen, Kagas, Vuojalahti, 241, 1986); it induced SCEs and UDS in human cells in vitro. It did not induce SCEs but did induce mutation and inhibited intercellular communication in Chinese hamster cells in vitro. It induced somatic mutation in Drosophila, but conflicting results were obtained for induction of SLRL mutations; it did not induce aeuploidy. It cause CAs and was mutagenic in plants. It induced mutation, gene conversion and mitotic recombination in yeast. It was not mutagenic to bacteria or bacteriophage. The n-butyl and iso-octyl esters of 2,4-D were also not mutagenic to bacteria (Mortelmans, haworth, Speck, 157, 1984)
(IARC Monographs, 15, 111)
          œ 1,2-Dichloropropane (Propyrene dichloride) i‚PC‚Q|ƒWƒNƒƒƒvƒƒpƒ“j (See also P-10)
           
   78-87-5@Industrial @@112.99
AM Sal./E. coli Max ( 2.5 mg/plate, }S9)
 
1)
AM Sal. Min ( 10 mg/plate, }S9) › 2)
AM Sal. Max ( 2 mg/plate, }S9)   3)
SOS E. coli Max ( ?) ,}S9   4)
UMU Sal. Max ( 0.47 mg/ml }S9)   5)
CA CHO Min ( 1.5 mg/ml, }S9) › 6)
MLY L5178Y Min ( 1.0 mg/plate, +S9) › 7)
SCE V79 Min ( 1.1 mg/ml, }S9) › 4)
SCE CHO Min ( 0.1 mg/ml, }S9) › 6)
UDS Human Ly Max ( 1.1 mg/ml }S9)   8)
SLRLv Drosophila Max ( 4.2 mg/ml, or)   9)
1) Ministry of Labour, Japan: Mutagenicity Test Data of Exist. Chem. Subst. JETOC (Ed.), Suppl.2, pp.39 (2000)   (Tables in English)  2) Haworth S et al., Environ. Mutagen., 5, 1-142 (1983)
3) US NTP Technical Rep. Series, 263 (1986)
4) von der Hude W., et al , Environ. Mutagen., 9, 401-410 (1987)
5) Ono Y.  et  al., Water Sci. Tech., 23, 329 (1991
6) Galloway CM, et al., Envron. Mol.. Mutagen., 10, 1-175 (1987)
7) Myhr BC & Caspary WJ, Envron. Mol.. Mutagen., 18, 51 (1991)
8) Perocco P., et al., Toxicol. Lett., 16, 69 (1983)
9) Woodruff RC., et al., Environ. Mutagen., 7, 677-702 (1989)
     
œ 2,3-Dichloro-1-propanol
i2,3-ƒWƒNƒƒ-1-ƒvƒƒpƒm[ƒ‹j

@@@      
616-23-9@@Industrial @ 128.99
AM Sal.. Min ( 0.2 ƒΚl/plate, }‚r9)
›
1)
CA CHL/IU Min (0.125 mg/ml/+S9), 6-18h @D20=0.055; TR=320
›
2)
1) Carr HS & rosenkranz HS: Mutation Res., 57, 381-384 (1978)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998) (Tables in English)

œ 1,3-Dichloropropene i1,3-ƒWƒNƒƒƒvƒƒyƒ“j
@@@ 542-75-6@Industry @ 110.98
AM Sal. Min ( 0.25 mg/plate, -S9); IR=8.5 x 103
›
1)
CA CHL/IU Min ( 0.04 mg/ml, -S9), 24h; @D20=0.52; TR=28 (with Poly, +MS9)
›
2)
MN Mice(ICR) Max (150 mg/kg, ip)   3)
1) Ishidate MJr (Ed): Data Book for Mutagenicity Tests on Chem.@in Bacteria, LIC/Tokyo (1991)   (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998)   (Tables in English)
3) Morita T. et al., Mutation Res., 329, 3-122 (1997)

yNotez@iCited from IARC Monographs Suppl., 6, 1987)
@@No data were available on the genetic and related effects of this compound in humans.
@@It induced UDS in human cells in vitro and SLRL mutation but not reciprocal translocations in Drosophila. Both the individual cis and trans isomers and a mixture of the two were mutagenic to bacteria.
(IARC Monographs, 41, 113)

      œ 2,2-Dichloropropionic acid (ƒWƒNƒƒƒvƒƒsƒIƒ“Ž_CDalaponj
@@      
75-99-0@Herbicide@@ 142.97
AM Sal.. (Sodium salt) Max (?)
 
1)
MB S. coelicolor
A3 (•ϊό‹Ϋj
(Sodium salt) Max (?)
 
2)
MB A.. nidurans
iƒRƒEƒWƒJƒrj
(Sodium salt) Max (?)
 
3)
MB S. cerevisiae
iy•κ‹Ϋj
(Sodium salt) @(Mitotic gene conversion) Max (?)
 
4)
1) Carere A, et al,: Mutation Res., 57, 277-286 (1978)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998)   (Tables in English)
3)
Bignami M, et al,: Mutation Res., 46, 395-402 (1977)
4) Siebert D & Lemperle E: Mutation Res., 22, 111-120 (1974)

œ Dichlorotetrafluoroethane (CFC-114)
@@@76-14-2 @Industry 170.92
AM Sal. Max (?)
 
1)
1) IPCS: Environ. health Criteria, 13, WHO/IPCS (1990)

œ 1,2-Dichloro-4-(t
rifluoromethyl) benzene  i1,2-ƒWƒNƒƒ-4-iƒgƒŠƒtƒ‹ƒIƒƒƒ`ƒ‹jƒxƒ“ƒ[ƒ“j
@@@328-84-7 @Industry   215.00
AM Sal. Max (1.25 mg/p;ate, }S9)
 
1)
1) Ministry of Labour, Japan: Mutagenicity Test Data of Exist. Chem. Subst. JETOC (Ed.), Suppl. 3, pp. 132 (2005) (Tables in English)

œ 2,6-Dichlorotoluene i2,6-ƒWƒNƒƒƒgƒ‹ƒGƒ“j
@@@@ 118-69-4@Industry@ 161.03
AM Sal. Max ( 0.6 mg/plate, }‚r9)
 
1)
CA CHL/IU Max ( 0.096 mg/ml, }‚r9)
 
1)
‚PjMinistry of Health, Labour & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 9 (2002) (Tables in English)

œ 2,2-Dichlorovinyl dimethyl phophate (Dichlorvos ; DDVP)
@@
62-73-7 @Insecticide @ 220.98
AM E. coli Min ( ? )
›
1)
AM Sal. Min ( 5 mg/plate, -S9) › 9)
AM Sal. Min ( ? )
›
2)
MB A. nidulans
(ƒRƒEƒWƒJƒrj
Min ( 14-28 mg/plate)
›
3)
MB E. coli Min ( 5 mg/L) › 4)
REC B. sub. Min ( 0.02 ml of 10% solution, -S9) › 11)
YM Yeast Min ( 19 mM)
›
4)
YM Yeast Min ( 40 mmol/L, -S9) › 12)
SLRLv Drosophila Max ( ? )
 
6)
SLRLv Drosophila Max (0.09 mg/kg, fed)   17)
CA CHL/IU Min ( 0.125 mg/ml, -S9), 48h: @D20= 0.13; TR= 80
›
5)
CA Hum. lym. Min ( 40 mg/L )   13)
CT Syr. ham. Min ( 0.45 mmol/L, -S9) › 14)
SCE CHO Min ( 0.5 mmol/L, -S9) › 15)
DNA E. coli Min ( 2 mg/ml ) › 16)
DLv Mice Max ( 4.8ƒΚ‚‡/l, po/ih) for 4 weeks
 
7)
DLv Mice Max ( 10 mg/kg, ip)   20)
CAv Mice, BM Max ( 0.015 mg/kg/day x 2, or)   18)
SCE Mice, BM Max ( 35 mg/kg, ip)   21)
MNv Mice, BM Max ( 0.015 mg/kg/day x 2, ip)   19)
SPA Mice Min ( 7.5 mg/ml,@}MS9),  6-18h:
›
8)
1) Bridges BA., et al.: Mutation Res., 19, 295-303(1973)
2) Carere A., et al.: Mutation Res., 57, 277-286 (1978)
3) Bignami M., et al. :Mutation Res., 46, 395-402 (1977)
4) Fahrig R.: IARC, Sci. Pub., 10m 161-181 (1974)
5) ‚h‚“‚ˆ‚‰‚„‚‚”‚… ‚l‚i‚’. i‚d‚„jF ‚c‚‚”‚ ‚a‚‚‚‹, ‚b‚ˆ‚’‚‚‚‚“‚‚‚‚Œ ‚`‚‚‚…‚’‚’‚‚”‚‰‚‚Ž ‚s‚…‚“‚” in vitro: LIC, Tokyo/Elsevier, Amsterdam (1988)
6) Sobels FH. & Todd K.: Mutation Res., 67, 89-92 (1979)
7) Dean BJ. & Blair D.: Mutation Res., 40, 67-72 (1976)
8) Wyrobek A., et al.: Proc. Natl Acad. Sci. (USA), 72, 4425-4429 (1975)
9) Moriya M., et al., Mutation Res., 116, 185-216 (1983)
10) Green MHL, et al., Mutation Res., 38, 33-42 (1976)
11) Shirasu Y., et al., Mutation Res., 40, 19-30 (1976)
12) Dean BJ et al., Arch Toxicol., 30, 61-66 (1972)
13) Dean BJ.,, Arch Toxicol., 30, 67-74 (1972)
14) Hatch GG., et al., Environ. Mutagen., 8, 515-531 (1986)
15) Tezuka H., et al., Mutation Res., 78, 177-191 (1980)
16) Rosenkranz HS., Canser Res., 33, 458-459 (1973)
17) Kramers PGN & Knaap AGAC, Mutation Res., 57, 103-105 (1978)
18) Paik SG & Lee SY, Korian J. Zool., 20, 19-28 (1977)
19) Dean BJ & Thorpe E, Arch Toxicol., 30, 39-49 (1972)
20) Epstein SS,  et al., toxicol. Appl. Pharmacol, 23, 288-325 (1972)
21) Klingerman AD, et al., Mutation Res., 157, 181-187 (1985)
@@@@
IARC Criteria for CarcinogenicityF@@
Group 2B
@i2003j

œ Diclomezine (ƒ‚ƒ“ƒK[ƒhj
@@@ 62865-36-5@ Pesticide 255.11
REC B. subtilis Max ( 3.0 mg/disk)
 
1)
AM Sal../E. coli Max ( 3.0 mg/plate, }S9)
 
1)
CA CHO Max ( 0.06 mg/ml, }S9)
 
1)
1) Sankyo Company. Ltd., J. Pesticide Sci., 13, 625-628 (1988)@@@@
œTop Page@iƒgƒbƒvƒy[ƒWj
œAbbreviation @iΘ—ͺ‹L†j@
œMutagenicity i•ΟˆΩŒ΄«j
œTest Systems@(ŽŽŒ±–@‚ΜŽν—ށj
œTechnical Problems@i‹Zp“I–β‘θ“_j
œList of@Compoundsi‰»‡•¨ƒŠƒXƒgj
œEvaluation of Results@iŽŽŒ±Œ‹‰Κ‚Μ•]‰Ώj