Group D-6 ‰»Šw\‘’@(Chemical Structure)  

œ Dicofol
(DTMC) iƒWƒRƒtƒH[ƒ‹j
@@ CASF 115-32-2@@Pesticide@@MW: 370.49
AM Sal. Max (?)
 
1)
CA CHL/IU Max ( 0.06 mg/ml, -‚r9), 24, 48h
 
2)
‚PjIARC Monog., Vol 30, 87 (1983)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)

œ 1,2-Dicyanobenzene i1C2-ƒWƒVƒAƒmƒxƒ“ƒ[ƒ“j(BCN)
@@@@91-15-6@ Industry@ 128.13
AM Sal./E.coli Max i 5.0 mg/plate, }S9j
 
1)
CA CHL/IU Min( 0.65 mg/ml, +S9), 6-18h; (Poly)
›
1)
‚PjMinistry of Health & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 8 (2001) (Tables in English)

œ 1,3-Dicyanobenzenei1C3-ƒWƒVƒAƒmƒxƒ“ƒ[ƒ“j
@@@@ 626-17-5@ Industry@ 128.13
AM Sal/E.coli Maxi 5.0 mg/plate, }S9j
 
1)
CA CHL/IU Max( 1.3 mg/ml, }S9), 6-18h
 
1)
‚PjMinistry of Health & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 4 (1996) (Tables in English)

œ 1,4-Dicyanobenzenei1C4-ƒWƒVƒAƒmƒxƒ“ƒ[ƒ“j
@@@
623-26-7@ Industry@ 128.14
AM Sal./E.coli Maxi 5.0 mg/plate, }S9j
 
1)
CA CHL/IU Max( 1.3 mg/ml, }S9), 6-18h
 
1)
‚PjMinistry of Health & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 3 (1996) (Tables in English)

œ DicyclohexylamineiƒWƒTƒCƒNƒƒwƒLƒVƒ‰ƒ~ƒ“j
@@@
101-83-7@ Industry@ 181.32
AM Sal./E.coli Maxi 5.0 mg/plate, }S9j
 
1)
CA CHL/IU Max( 2.2 mg/ml, +S9), 6-18h
’
1)
‚PjMinistry of Health & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 6 (1998) (Tables in English)

yNotez (Cited from IARC Monograph Suppl., 6 (1987)
@@No data were available on the genetic and related efects of this agent in humans.
@@It induced CAs in cultured human lymphocytes, It was not mutagenic to bacteria.
œ N, N-Dicyclohexyl-2-benzothiazolesulfenamideiN, N-ƒTƒCƒNƒƒwƒLƒVƒ‹-
@@@2-ƒxƒ“ƒ]ƒ`ƒAƒ][ƒ‹ƒXƒ‹ƒtƒFƒiƒ~ƒh
j
@@@
4979-32-2 @Industry@ 346.59
AM Sal./E.coli Maxi 5.0 mg/plate, }S9j
 
1)
CA CHL/IU Max( 0.82 mg/ml, -S9), 24h; (also Poly)
’
1)
MN CHL/IU Min( 0.21mg/ml, -S9), 48h
›
1)
‚PjMinistry of Health & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 3 (1996) (Tables in English)

œ Dicyclohexylcarbodiimide iƒWƒTƒCƒNƒƒwƒLƒVƒ‹ƒJƒ‹ƒ{ƒWƒCƒ~ƒhj
@@@
538-75-0 @Industry@ 206.33
AM Sal./E.coli Maxi 2,5 mg/plate, }S9j

@@ 

1)
CA CHL/IU Max( 0.03 mg/ml, }S9), 6-18h

@@ 

1)
‚PjMinistry of Health & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol.1 (1994) (Tables in English)

œ Dicyclopentadiene iƒWƒTƒCƒNƒƒyƒ“ƒ^ƒWƒ“j
@ @@ 77-73-6@@Industrial @ 132.22
AM Sal./E.coli Maxi 5.0 mg/plate, }S9j
 
1)
CA CHL/IU Max( 0.10mg/ml,@6-18h, +S9)
’
1, 2)
‚PjMinistry of Health & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 3 (1996) (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998) (Tables in English)


US-NTP Genotoxicity ScreeningF
›AmesTestF@ 

œ Dicyclopentadienytl iron@iƒWƒVƒNƒƒyƒ“ƒ^ƒWƒFƒjƒ‹“SGƒtƒFƒƒZƒ“j
@@@@ 102-54-5@Industrial /Catalyst 175.96
SLRL Drosophila Min ( 30% of lethal dose), 24h
›
1)
‚PjZimmering S., et al.: Environ. Mutagenesis, 7, 87-100 (1985)
@
@
US-NTP Genotoxicity ScreeningF

› AmesTestF@’
›
CA Test with CHO Cells F@ 
› SCE Test with CHO Cells:F@›
› Reciprocal Translocation Test with DrosophilaF
@›

œ Dicyclopentylsilanediol iƒWƒVƒNƒƒyƒ“ƒ`ƒ‹ƒVƒ‰ƒ“ƒWƒI[ƒ‹j
@@@
211495-85-1@@Industry@ 200.35
AM Sal./E.coli Maxi2,5 mg/plate, }S9j
 
1)
CA CHL/IU Max( 0.3 mg/ml, }S9), 6-18h
 
1)
‚PjMinistry of Health & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 8(2) (2001) (Tables in English)

œ Dienochlor@iƒWƒmƒNƒ[ƒ‹j
@@@ 2227-17-0@Pesticide @ 474.6
REC B. subtilis Max ( 0.01 mg/disk)
 
1)
AM Sal/E. coli Max ( 5,0 mg/plate, }S9)
’
1)
1) Agro Kane Sho, Co. Ltd.: J. Pesticide Sci., 15, 511-514 (1990) @

œ Dieldrin@iƒfƒBƒ‹ƒhƒŠƒ“j
@@@ 60-57-1@@Insecticide@@@ 380.93
AM Sal. Max (?)
 
1)
CA WI-38 Min( 1ƒΚg/ml,|S9), 24h
›
2)
‚Pj McCann J., et al. : Proc. Natl Acad. Sci. (USA), 72, 5135-5939 (1975)
 2) Majumdar SK., et al.: J. Hered., 67, 303-307 (1976)

@@@
US-NTP Genotoxicity ScreeningF

› AmesTestF@ 
› Mouse Lymphoma Assay (L517Y)F@
›
› CA Test with CHO CellsF@ 
› SCE Test with CHO CellsF@›

yNotez(Cited from IARC Monograph Suppl., 6 (1987)
@@In one study, CAs were not found in peripheral blood lymphocytes of workers exposed to this agent.
@@It did not induce DL mutation in mice or CAs in bone-marrow cells of Chinese hamsters treated in vivo. It induced UDS in transformed human fibroblasts but not in rat hepatocytes; it did not induce single-strand breaks in Chinese hamster V79 cells. It inhibited intercellular communication in human and rodent cell systems. it did not induce SLRL mutation in Drosophila, was not mutagenic to bacteria and did not induce breakage of plasmid DNA.

œ 1,2: 3,4-Diepoxybutane (
DBE)
i1,2: 3,4-ƒWƒGƒ|ƒLƒVƒuƒ^ƒ“j

@@@ 1464-53-5@@Industry/Laboratory@@@ 86.09
DNA E. coli (repair) Min ( 50 ƒΚg/well) › 1)
YM S. serev. Min ( 5x10 -3M) › 2)
CA Vicia faba Min ( 4x10 -5M) › 3)
PLNv Maise Min ( 0.2%) › 4)
CT Syr. Ham. Min ( 0.05 ƒΚg/ml) › 5)
MNv Mice (CD-1) Min ( 36 mg/kg, po)
›
6)
1) Ichinotusubo D., et al., Mutation Res., 46, 53-62 (1977)
2) Zimmermann, FK: Mutation Res., 11, 327-337 (1969)
3) Swietlinska Z: Mutation Res., 16, 41-47 (1972)
4) Krizinger D: Genetics, 45, 143-154 (1960)
5) Pienta RJ et al: Int. J. Cancer, 19, 642-655 (1977)
6) Morita T., et al., Mutation Res., 389, 3-122 (1997)


œ Diethanolamine@iƒfƒBƒGƒ^ƒm[ƒ‹ƒAƒ~ƒ“, DEAj@
@@@ 111-42-2@@Detergent@@@ 105.14
AM Sal. Max (?)
 
1-3)
MLA L5178Y Max (?)
 
4)
YM Yeast (Mitotic gene conversion) Max (?)
 
3)
CA CHO Max (?)
 
5)
SCE ‚b‚g‚n@ Max (?)
 
5)
CA Rat R‚k‚P Max (?)
 
3)
CT Ham/Embryo Max (?)
 
6)
Other (NBP-Test) ( Reaction with 4-ip-nitrobenzyljpyridine), Max (?)
 
1)
‚PjHedenstedt A.: Mutation Res., 53, 198-199 (1978)
2) Haworth S., et al.: Environ. Mutagen. 5 (Suppl. 1), 1-142 (1983)
3) Dean BJ., et al.: Mutation Res.., 153, 57-77 (1985)
4) Myhr BC., et al.: Environ. Mutagen. 8 (Suppl. 6), 58-93 (1986)
5) Loveday KS., et al.: environ. Mol. Mutagen., 13, 69-94 (1989)
6) Inoue K., et al.: Mutation Res., 101, 305-313 (1982)


œ Diethanolnitrosamine
@iƒWƒGƒ^ƒm[ƒ‹ƒjƒgƒƒTƒAƒ~ƒ“j (See also N-5)
@@@@ 1116-54-7@ Laboratory@ 134.13
AM Sal. Max (?)
 
1)
CA CHL/IU Min( 5.0 mg/ml,|S9), 24h; D20= 4.3; TR= 4.0
›
2)
‚Pj (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test i In Vitro, LIC, Tokyo (1998) (Tables in English)

œ Diethylamine@@iƒWƒGƒ`ƒ‹ƒAƒ~ƒ“GDENj
@@
106-46-7@ Industry@@ 37.14
AM E. coli Max (?)@
 
1,2)
MB C. intermedia
iƒJƒ“ƒWƒ_j
Max (?)
 
3)
MB K.rhinosclerom. i•@dŽξ‹Ϋj Max (?)
 
4)
DLv Rats Max (?)iih)@
 
5)
MNv Rats Max (?)
 
5)
UDSv Rat/Kidney Max (?)
 
6)
CA Vicia fabia
(ƒ\ƒ‰ƒ}ƒj
Min(?) ›
7)
‚PjHedenstadt A.: Mutation Res., 53, 198-199 (1978)
2) Zeiger E., et al.: Environ. Mutagen., 9 (Suppl 9), 1-110 (1987)
3) Ali AMM., et al.: Egypt. J. Microbiol., 19, 89-94 (1984)
4) Ali AMM,, et al.: Egypt. J. Microbiol., 14, 1-2 (1979)
5) Legator M., et al.: Environ. Res., 20, 99-124 (1979)
6) Loury DJ., et al.: Toxicol. Appl. Pharmacol. 87, 127-140 (1987)
7) Galal HE. & Abd-Alla SA.: Egypt J. Genet. Cytol. 5, 262-280 (1976)@
@

US-NTP Genotoxicity ScreeningF
@›Ames TestF@ 

œ 2-Diethylaminoethanol @i2-ƒWƒGƒ`ƒ‹ƒAƒ~ƒmƒGƒ^ƒm[ƒ‹G@DEAEj
@@@ 100-37-8@ @Industry@@@ 117.19
AM Sal Max (?)@
 
1)
‚Pj Zeiger E. et al.: Environ. Mutagen., 9 (Suppl. 9), 1-110 (1987)

US-NTP Genotoxicity ScreeningF
@› AmesTest F@
 
œ 2-(Diethylamino) ethyl methacrylatei2-(ƒWƒGƒ`ƒ‹ƒAƒ~ƒm)ƒGƒ`ƒ‹ƒƒ^ƒNƒŠƒ‰[ƒgj
@@@
105-16-8 @Industry@ 185.27
AM Sal./E.coli Maxi 5.0 mg/plate, }S9j
 
1)
CA CHL/IU Min( 0.3 mg/ml, +S9), 6-18h; (Poly also)
›
1)
‚PjMinistry of Health & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 6 (1998) (Tables in English)
œ N,N'-Diethylaniline@(DEA)
@@
91-66-7@Industry@ 149.24
AM Sal/E.coli Maxi 0.156 mg/plate, }S9j
 
1)
‚PjMinistry of labour, Japan: Mutagenicity Test Data of Exist. Chem. Subst., Suppl (1997) (in Japnese) (Tables in English)

œ
1,4-Diethylbenzene i1C4-ƒWƒGƒ`ƒ‹ƒxƒ“ƒ[ƒ“j

@@ 105-05-5@Industry@ 134.22
AM Sal./E. coli Max ( 0.078 mg/plate, }S9)
 
1)
CA CHL/IU Max ( 1.13 mg/mg, }S9), 6-18h
 
1)
‚PjMinistry of Health & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 2 (1995) (Tables in English)

œ Diethylene glycol
i
ƒWƒGƒ`ƒŒƒ“ƒOƒŠƒR[ƒ‹j

@@@ 111-46-6 @ Industry@@@ 106.12
AM Sal. Max@(?)
 
1)
CA CHL/IU Max ( 40 mg/mg), }S9 iPositive at only at very high dose)
’
2)
‚PjZeiger E. et al.: Environ. Mutagen., 9 (Suppl. 9), 1-110 (1987)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998) (Tables in English)


œ Diethylene glycol dimethyl ether iƒWƒGƒ`ƒŒƒ“@ƒOƒŠƒR[ƒ‹ ƒWƒƒ`ƒ‹ƒG[ƒeƒ‹j(Diglyme)
@@@ 111-49-6 @ Industry@@@ 134.17
yNotez@(Cited from CICADs Documents,1, 1998))
  Diglyme was not mutagenic in several Ames tests with or without S9 mix (Hoechst, 1979; McGregor et al., 1983; Mortelmans et al., 1986).
  Diglyme also had no effect in a test for unscheduled DNA synthesis in human embryo fibroblasts (McGregor et al., 1983).
  Diglyme did not induce chromosomal aberrations in bone marrow cells in groups of 10 male and 10 female CD rats exposed to 250 or 1000 ppm (1395 or 5580 mg/m3) diglyme 7 h/day for 1 or 5 days (McGregor et al., 1983).   A dominant lethal test is described in section 8.7.1.1 (McGregor et al., 1983). The reduced number of pregnancies and an increase in preimplantation losses may be due either to a dominant lethal effect or to reduced fertility of the males. Considering the known effects of diglyme on fertility, the authors of the study assume that reduced fertility is a cause of the effects. Also, the post-implantation losses may be due to reduced fertility instead of a dominant lethal effect, as it is known that early deaths may be a consequence of a low number of implantations.
  A recessive lethal test on Drosophila melanogaster exposed to 250 ppm (1395 mg/m3) for 2.75 h could not be evaluated because of an unusually high death rate in a control group (McGregor et al., 1983).

References
E McGregor DB, Willins MJ, McDonald D, Holmstrom M, McDonald D, Niemeier RW : Genetic effects of   2-methoxyethanol and
     bis(2-methoxyethyl)ether. Toxicology and applied pharmacology, 70: 303-316. (1983)
E Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B, Zeiger E (1986) Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environmental mutagenesis, 8(S7): 1-119 (1986)
E@Hoechst (1979)@(unpublished)

œTop Page@iƒgƒbƒvƒy[ƒWj
œAbbreviation @iΘ—ͺ‹L†j@
œMutagenicity i•ΟˆΩŒ΄«j
œTest Systems@(ŽŽŒ±–@‚ΜŽν—ށj
œTechnical Problems@i‹Zp“I–β‘θ“_j
œList of@Compoundsi‰»‡•¨ƒŠƒXƒgj
œEvaluation of Results@iŽŽŒ±Œ‹‰Κ‚Μ•]‰Ώj