Group D-9 化学構造　(Chemical Structure)  
● 2,5-Dimethoxy-4-methylamphetamine-HCl
　　　CAS：15589-00-1　　　Labouratory　　MW: 245.78
CA CHL/IU  Max ( 0.06 mg/ml, -Ｓ9), 24h
□
1)
1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In vitro,LIC, Tokyo (1998) (Tables in English)

● Dimethyl acetamide 　（ジメチルアセトアミド； DMA）　
　　　 127-19-5　Industry　　　 87.12

　　US-NTP Genotoxicity Screening：
　 　○　Ames Test：　□

● Dimethylamine　 （ジメチラミン；DMA）
　　 　　124-40-3　　　Industrial 　　　45.08
AM Sal.  Min (?)
○
1)
HMA Mice  Max (?)
□
1)
SM CHO/HGPRT  Max ( 1.0 mg/ml)
□
2, 3)
UDS Rat Hepatocytes  Max (?)
□
4)
AM Sal.  （DMA-HCl）Max(?)
□
5)
CA CH /Fb  （DMA-HCl）Max(?)
□
5)
CA CHL/IU  Max （0.12 mg/ml, -S9）, 24h
□
6)
１） Green NR. & Savage JR.: Mutation Res., 57,115-121 (1978)
2) Hsie AW., et al.: Fed Proc. 37, 1384 (Abstract 633) (1978)
3) Hsie AW., et al.: Proc. of NATO Advanced Research Institute on the In vitro Toxicity of Environtal Agents, pp.283-302，
　　NTIS Pub., Conf-790951-1, Nat. Tech. Inf. Service, Springfield, VA (1980)
4) Martelli A., et al.: Mutation Res., 122, 373-376 (1983)
5) Kawachi T., et al.: Appl. Methods. Oncol. 3, 253-267 (1980)
6) Ishidate MJr., et al.: Mutation Res., 48. 337-354 (1977)
　　
US-NTP Genotoxicity Screening：
　 ○Ames Test：　□

● 4-Dimethylaminoantipyrine 　(Aminopyrine)
　　　 58-15-1　Medicine　　　 231.29
AM Sal./E. coli  Max (?)
□
1)
CA CHL/IU  Max ( 1.0 mg/ml)
□
2)
1) (?)　
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In vitro, LIC, Tokyo (1998) (Tables in English)

● 4-Dimethylaminoazobenzene （4-ジメチルアミノアゾベンゼン） （DAB; Butter Yellow)
　　　 60-11-7　Laboratory　　 225.29
DNA Repair (B. sub.)  Max（?)
□
1)
AM Sal.  Max ( 1 mg/plate, ±S9）
□
2)
UDS HeLa cells  Min ( 10-8 M)
○
3)
CT BHK21c113  Min ( 25 μg/ml, +S9)
○
4)
CT Rat embryo.  Min （10 μg/ml)
○
5)
SCE CHO  Min (?)
○
7)
1) Kada T., et al., Mutation Res., 16, 165 (1972)
2) Brown JP., et al., Mutation Res., 56, 249 (1978)
3) (?)
4) Ashby J., et al., Br. J. Cancer, 38, 34-50 (1978)
5) Freeman AE., et al., J. Natl. Cancer Inst., 51, 799 (1973)
● 2-(Dimethylamino) ethyl acrylate （アクリル酸 2-(ジメチルアミノ)エチル−エーテル））
　　　 2439-35-2 　Industry　　 143.21
AM Sal./E. coli  Min ( 0.625 mg/plate, -S9)
○w
1)
AM Sal.  Miax( 10 mg/plate, -S9) □ 2)
CA CHL/IU  Min ( 0.01 mg/ml, -S9) , 6h
○
1)
CA Hum. lym.  Min ( 0.04 mg/ml, -S9) , 6h ○ 3)
MNv Mice, BM  Miax( 75 mg/kg x 2, ip ) □ 4)
1) Ministry of Health, Labour & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 5 (1997)  (Tables in English)
2) Zeiger E., et al., Environ. Mutagen., 9(Suppl. 9), 1-100 (1987
3) Atochem Inc., US-EPA Doc. No. 89-910000064, NTIS, OTSO529917 (1991)
4) EU, IUCLID, ver 3.1.1 (2000)

● 2-(Dimethylamino) ethylmethacrylate (メタクリル酸2-（ジメチルアミノ）エチル）（See also M-3)
　　　 2867-47-2　Insustry 　 157.24
AM Sal/E. coli  Min ( 2.5 mg/plate, -S9)
○w
1)
AM Sal.  Max ( 5.0 mg/plate,±S9) □ 2)
SM V79  Max ( 0.5 mg/ml, -S9) □ 3)
CA CHL/IU  Min ( 0.4 mg/ml, -S9), 6-18h; D20= 0.19
○
1)
CA Hum. lym.  Min ( 1.1 mg/ml, -S9) ○ 4)
MNv Mice, BM  Max (1.0 g/kg, or) □ 5)
MNv Mice, BM  Max (0.2 g/kg , ip) □ 6)
1) Ministry of Health, Labour & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 6 (1998)　(Tables in English)
2) Atochem, CTT 7331, MMO (1991)
3) Atochem, CTT 8515, MVA (1991)
4) Hazleton, 11/HLC (1991)
5) Roehm, Rep. No. 89-002 (unpublished)(1989)
6) Atochem, CTT 9776, MAS (1993)

● 2-Dimethylaminopiridine(DMAP)
　　　 1122-58-3　Industry　 122.17
AM Sal/E. coli  Max ( 5 mg/plate, ±S9)
□
1)
1) Ministry of Labour, Japan: Mutagenicity Test Data of Exist. Chem. Subst., JETOC (Ed.) (1996) (Tables in English)
● N, N-Dimethylaniline 　（N, N-ジメチルアニリン）
　　　 121-69-7　Industry/Solvent　　 121.18
AM Sal.  Max （1.0 mg/plate, ±S9)
□
1-3)
AM Sal./ E.coli  Max （0.625 mg/plate, ±S9) □ 8)
MLA L5178Y  Max (?)
□
4)
UDS Hepatocytes  Max (?)
□
5)
DNA Mouse/Testis  Max (?)
□
6)
CA CHO  Min (?)
○
7)
CA CHL/IU  Min ( 0.05 mg/ml, +S9), 6h;  D20= 0.037; TR= 1000 ○ 9)
SCE CHO  Min (?)
○
7)
1) Mori Y., et al.: Carcinogenesis, 1, 121-127 (1980)
2) Ho CH., et al.: Mutation Res. 85, 335-345 (1981)
3) Mortelmans K., et al.: Environ. Mutagen., 8 (Supple. 7), 1-119 (1986)
4) NTP: Technical Report 360; DHHS (NIH) Pub. No. 89-2815, NTP, NC (1990)
5) Yoshimi N., et al.: Mutation Res., 206, 183-191(1988)
6) Seiler JP.: Mutation Res., 46, 305-310 (1977)
7) Loveday K., et al.: Environ. Molec. Mutagen, 13, 60-94 (1989)
8) Ministry of Labour, Japan: Mutagenicity Test Data of Exist. Chem. Subst., JETOC (Ed.), Suppl., pp. 211 (1997) (Tabeles in English)
9) Ministry of Labour, Japan: Mutagenicity Test Data of Exist. Chem. Subst., JETOC (Ed.), Suppl 3., pp. 260 (2005) (Tables in English)

 US-NTP Genotoxicity Screening：　
 ○ Ames Test：　□
 ○ MLA Test：　○
 ○ CA Test with CHO Cells：　○
 ○ SCE Test with CHO Cells：○

● 2,3-Dimetylaniline （2,3-ジメチルアニリン）(2,3 キシリジン）
　　　 87-59-2　Insustry 　 121.20
AM Sal./E. coli  Min ( 1.25 mg/plate, +S9)
○w
1)
AM Sal..  Max ( 3 mg/plate, ±S9
□
2)
AM Sal.  Min ( +S9) ○ 3)
AM Sal.  Min ( 6mg/plate, +S9) ○ 4)
AM Sal./E. coli  Min ( 1.8 mg/plate, +S9) ○ 5)
CA CHL/IU  Min ( 0.6 mg/ml, +S9), 6h; D20= 0.19 ○w 1)
1) Ministry of Health, Labour & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 5 (1997)　(Tables in English)
2) Florin I et al., Toxicol. 18, 219-230 (1980)
3) Nohmi T., et al., Mutation Res., 136, 159-168 (1984)
4) Zeiger E., et al., Environ. Mol. Mutagen., 11, 1-157 (1988)
5) Zimmer D., et al., Mutation Res., 77,317-326 (1980)

● 2,4-Dimethylaniline　（2，4-ジメチルアニリン）(2,4-Xylidine)
　　 95-68-1　Insustry 　 121.18
CA CHL/IU  Min ( 0.025 mg/ml, +S9), 6-18h; (Poly also); D20= 0.073
◎
1)
1) Ministry of Labour, Japan: Mutagenicity Test Data of Exist. Chem. Subst., JETOC (Ed.) (1996) (Tabeles in English)
● 3,4-Dimethylaniline　（3，4-ジメチルアニリン）
　　　 95-64-7　Insustry 　 121.20
CA CHL/IU  Max ( 0.47 mg/ml, ±S9), 6-18h
□
1)
1) Ministry of Health, Labour & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 3 (1996)　(Tables in English)

● 3,5-Dimethylaniline　（3，5-ジメチルアニリン）
　　　 108-69-0　Insustry 　 121.20
CA CHL/IU  Min ( 0.9 mg/ml, ±S9), 6-18h
○w
1)
1) Ministry of Health, Labour & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 5 (1997)　(Tables in English)

● 7,12-Dimethylbenz(a)anthracene （7，12-ジメチルベンツ(a)アントラセン）
　　　 57-97-6　Labouratory/Carcinogen 　　 256.35
AM Sal  Min（ 0.02 mg/plate, +S9)
○
1)
CA Human LY  Min（ 0.1 mg/ml, +S9)
○
2)
CA CHL/IU  Min ( 0.25 mg/ml, +S9), 3h
○
3)
SCE V79  Min（ 0.001 mg/ml, +S9)
○
4)
UDS Rat Hepatocytes  Min（ 10-3M)
○
5)
UDS HeLa cells  Min（ 10-7M)
○
6)
CT BALB/3T3  Min（ 0.05 μg/ml)
○
7)
CT C3H 10T1/2  Min（ 0.1 μg/ml)
○
8)
MNv Rats (SD)  Min（ 10 mg/kg), ip
○
9)
CTv Rats  Min (?)
○
10)
1) McCann J, et al., Proc. Natl. Acad. Sci.(USA), 72, 979-983 (1975)
2) Brookes P: Mutation Res., 39, 257-284 (1977) (A Review)
3) Matsuoka A, et al,: . Mutation Res., 66, 277-290 (1979)
4) Popescu NC, et al,: J. Natl . Cancer Res., 59, 289-293 (1977)
5) Williams GM: Cancer Res., 37, 1845-1851 (1977)
6) Martin CN. et al,: Cancer Res., 38, 2621-2627 (1978)
7) DiPaolo JA, et al,: Cancer Res, 32, 2686-2695 (1972)
8) Reznikoff CA, et al,: Cancer Res., 33, 3239-3249 (1973)
9) Trzos RJ, et al, Mutation Res., 58, 79-86 (1978)
10) Sugiyama T, et al,: (?)

● N, N-Dimethylbenzylamine （N, N-ジメチルベンジラミン）
　　　 103-83-3　Insustry 　 135.23
AM Sal/E. coli  Max ( 5.0 mg/plate,±S9)
□
1)
CA CHL/IU  Min ( 0.375 mg/ml, +S9), 6h
○
1)
1) Ministry of Health, Labour & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 5 (1997)　(Tables in English)

● 3,3'-Dimethyl-4,4'-biphenylene diisocyanate
　　 91-97-4　Insustry 　 264.29
CA CHL/IU  Min ( 0.6 mg/ml, +S9), 6h; D20= 0.79
○w
1)
1) Ministry of Labour, Japan: Mutagenicity Test Data of Exist. Chem. Subst., JETOC (Ed.) (1996) (Tabeles in English)
● N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine
　　（N-(1, 3-ジメチルブチル)-N'-フェニル-p-フェニレンジアミン）
　　　 793-24-8　Industry　 268.40
AM Sal/E. coli  Max ( 2.5 mg/plate, ±S9)
□
1)
CA CHL/IU  Max ( 0.01 mg/ml, -S9), 24h
○
1)
1) Ministry of Health & Welfare (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 7 (1999)  (Tables in English)

● Dimethyl carbamoyl chloride （ジメチルカルバモイルクロライド；DMCC）
　　　　 79-44-7　　Industrial /Intermediate　　 107.54
AM Sal  Min (?)
○
1-3)
YM Yeast  Min (?)
○
1)
MLA L5178Y  Min (?)
○
1)
UDS Rat Hepatocytes  Max (?)
□
1)
DNA CHO  Min (?)
○
1)
CA CHO  Min（ 0.0167μg/l, +Ｓ9), 1-12h
○
4)
CT BHK21c  (Soft-agar method) 　Min (?)
○
5)
１）IARC: An Updating of IARC Monographs Vol 1-42, pp. 199-200, Lyon, France (1987)
2) McCann J, et al., Proc. Natl. Acad. Sci.(USA), 72, 979-983 (1975)
3) Purchase IFH, et al,: Nature, 264, 624-627 (1976)
4) Natarajan AT., et al.: de Serres FJ & Ashby J. (Eds), Prog. Mutation Res., Vol. 1, pp.551-559, Elsevier (1981)
5) Styles JA: Br. J. Cancer, 37, 931-936 (1978)
　 　
US-NTP Genotoxicity Screening：
○ Ames Test：　○
○ Mouse Lymphoma Test ：　○
○ CA Test with CHO Cells：　○
○ SCE Test with CHO Cells：　○
○ SLRL Test with Drosophila：　○
○ Reciprocal Toranslocation Test　with Drosophila：　□

IARC Carcinogenicity Criteria：
Group 2A (Probably carcinogenic in humans)

【Note】 (Cited from IARC Monograph, Suppl. 6 (1987)
　　No data were available on the genetic and related effects of this compound in humans.
　　It induced MNs but not SCEs in mice treated in vivo. It did not cause UDS in human fibroblasts in vitro. It induced CA of Syrian hamster embryo cells and CAs in CHO cells; conflicting results were obtained with regard to the induction of SCEs. It was mutagenic to mouse lymphoma cells; it did not induce UDS in rat hepatocytes but did induce DNA strand breaks in Chinese hamster cells. It did not induce SLRL mutations in Drosophila; it induced aneuploidy, mutation, gene conversion and DNA damage in Yeast. It was mutagenic to bacteria and caused DNA damage.

● Dimethyldithio carbamate 　（サンケル）
　　　 15521-65-0　Pesticide/Anti-bacteria 　　 299.1
REC B. subtilis  Max ( 2.0mg/disk)
□
1)
AM Sal./E. coli  Max (?)
□
1)
CA CHL/IU  Max ( 0.035μg/mｌ, -S9), 24h：
 Min ( 0.3 mg/ml, ±S9）, 6h
□
○
1)
１）Mikasa Kagaku, Co. Ltd. : J. Pesicide Sci., 17, S25-S27 (1992)

● Dimethylethoxysilane　（ジメチルエトキシシラン；　DMES） 　　　
　　　　 14857-34-2　Waterproofing 　　 104.2
AM Sal./E. coli  Max ( 3.0 μｇ/plate, ±Ｓ9)
□
1)
SM CHO  Max ( 40μl/ml; ±S9)
□
2)
１） Kirby PE.: (Unpublished report), Sitek Research Lab. , Rockville, MD (1991)
2)　Pant KJ.: (Unpublished report), Sitek Research Lab. , Rockville, MD (1991)

● N,N-Dimethylformamide （N,N-ジメチルホルマミド；　DMF)　
　　　　 68-12-2　Industrial /Solvent　　 73.09
AM Sal.  Max (?)
□
1)
AM Sal./E. coli  Max ( 5.0% vapor, ±S9) □ 5)
UDS Rat/Hepatocites  Max (?)
□
2)
CT SH  Max (?)
□
3)
CT BHK 21c 113  Max (?)
□
4)
1) Purchase IFH., et al.: Nature, 246, 624-627 (1976)
2) Williams GM.: Cancer Res., 37, 1845-1851 (1977)
3) Pienta RJ., et al.: Internat. J. Cancer, 19, 642-655 (1977)
4) Styles JA.: Brit. J. Cancer, 37, 931-936 (1978)
5) Ministry of Labour, Japan: Mutagenicity Test Data of Exist. Chem. Subst., JETOC (Ed.), Suppl. 3., pp. 177 (2005) (Tables in English)

 US-NTP Genotoxicity Screening：
 ○ Ames Test (±S9): 　□
 ○ MLA Test: 　○w
 ○ SLRL Test with Drosophila:　□
 ○ CA Test with CHO Cells:　　 □
 ○ SCE Test with CHO Cells: 　□

 IARC Criteria for Carcinogenicity:
  Group 2B 　(Possibly carcinogenic to humans)

【Note】　(Cited from CICADs Documents 31, 2001)

   The results of assays for gene mutation in vitro were almost entirely negative. Of 20 identified assays in Salmonella, results were negative in 18 (Green & Savage, 1978; Purchase et al., 1978; Baker & Bonin, 1981; Brooks & Dean, 1981; Garner et al., 1981; Gatehouse, 1981; Ichinotsubo et al., 1981; MacDonald, 1981; Martire et al., 1981; Nagao & Takahashi, 1981; Richold & Jones, 1981; Rowland & Severn, 1981; Simmon & Shepherd, 1981; Skopek et al., 1981; Venitt & Crofton-Sleigh, 1981; Antoine et al., 1983; Falck et al., 1985; Mortelmans et al., 1986), and two had equivocal results (Hubbard et al., 1981; Trueman, 1981). Results in six assays in Escherichia coli were all negative (Gatehouse, 1981; Matsushima et al., 1981; Mohn et al., 1981; Thomson, 1981; Venitt & Crofton- Sleigh, 1981; Falck et al., 1985).

   Although fewer assays for cytogenetic effects and genotoxicity in vitro were identified than for gene mutation, results were also predominantly negative. In assays for chromosomal aberrations (CAs), results were negative for human lymphocytes (Antoine et al., 1983) and Chinese hamster ovary (CHO) (Natarajan & van Kesteren-van Leeuwen, 1981) and weakly positive in human peripheral lymphocytes (Koudela & Spazier, 1979). In three mouse lymphoma assays, results were negative (Jotz & Mitchell, 1981; Mitchell et al., 1988; Myhr & Caspary, 1988) and one was weakly positive (McGregor et al., 1988). Results of in vitro tests for sister chromatid exchange (SCE) were negative in three assays in CHO (Evans & Mitchell, 1981; Natarajan & van Kesteren-van Leeuwen, 1981; Perry & Thomson, 1981) and one in human lymphocytes (Antoine et al., 1983). Assays for unscheduled DNA synthesis (UDS) were negative in human fibroblasts (Agrelo & Amos, 1981; Robinson & Mitchell, 1981), mouse hepatocytes (Klaunig et al., 1984), and HeLa cells (Martin & McDermid, 1981), while in assays in rat hepatocytes, results were both negative (Ito, 1982) and positive (Williams, 1977). Results of assays for DNA repair in mouse (McQueen et al., 1983) and hamster (McQueen et al., 1983) hepatocytes were also negative. An assay for DNA repair in human hepatocytes had negative results (McQueen et al., 1988).

   The database for genotoxicity studies in vivo is more limited than that for in vitro studies.

    In two adequate assays for micronucleus induc tion, results were negative (Kirkhart, 1981; Antoine et al., 1983). In the latter study, dose levels were too widely spaced, and the top dose was 2000 mg/kg body weight. Results were also negative in two assays in which there were no positive controls (Salamone et al., 1981; Tsuchimoto & Matter, 1981). It should be noted that Salamone et al. (1981) observed no effect at doses up to 80% of the LD50. An assay in which an increase in micronuclei was observed in bone marrow of mice was reported only as an abstract (Ye, 1987), although a dose-response was not clear. Although six dose levels were included in the protocol, the highest dose was only 20 mg/kg body weight (oral LD50 values in Labouratory animals range from 2000 to 7000 mg/kg body weight).
   
   Negative results were reported in assays for chro mosomal damage in bone marrow of rats (Sheveleva et al., 1979; McGregor, 1981) and dominant lethal assays in rats (Lewis et al., 1979; McGregor, 1981; Cragin et al., 1990). Limited reporting (abstracts, secondary sources) precluded critical review of these studies.

    Quantitative data were not presented in a report of an assay in which SCEs were not observed in bone marrow of mice (Paika et al., 1981)

.References
・Agrelo C, Amos H (1981) DNA repair in human fibroblasts. In: DeSerres FJ, Ashby J, eds. Evaluation of short-term tests for carcinogens. Report of the International ColLabourative Program. New York, NY, Elsevier, pp. 528-532 (Progress in Mutation Research, Vol. 1).
・Antoine JL, Arany J, Leonard A, Henrotte J, Jenar-Dubuisson G, Decat G (1983) Lack of mutagenic activity of dimethylformamide. Toxicology, 26:207-212.
・Baker RSU, Bonin AM (1981) Study of 42 coded compounds with the Salmonella/mammalian microsome assay. In: DeSerres FJ, Ashby J, eds. Evaluation of short-term tests for carcinogens. Report of the International ColLabourative Program. New York, NY, Elsevier, pp. 249-260 (Progress in Mutation Research, Vol. 1)
.・Brooks TM, Dean BJ (1981) Mutagenic activity of 42 coded compounds in the Salmonella/microsome assay with preincubation. In: DeSerres FJ, Ashby J, eds. Evaluation of short-term tests for carcinogens. Report of the International ColLabourative Program. New York, NY, Elsevier, pp. 261-270 (Progress in Mutation Research, Vol. 1).
・Cragin DW, Lewis SC, McKee RH (1990) A dominant lethal test of dimethyl formamide. Environmental and molecular mutagenesis, 15(Suppl.17): 14 (Abstract 44)
・Evans EL, Mitchell AD (1981) Effects of 20 coded chemicals on sister chromatid exchange frequencies in cultured Chinese hamster cells. In: DeSerres FJ, Ashby J, eds. Evaluation of short-term tests for carcinogens. Report of the International ColLabourative Program. New York, NY, Elsevier, pp. 538-550 (Progress in Mutation Research, Vol. 1).
・Falck K, Partanen P, Sorsa M, Suovaniemi O, Vainio H (1985) Mutascreen, an automated bacterial mutagenicity assay. Mutation research, 150:119-125.
・Garner RC, Welch A, Pickering C (1981) Mutagenic activity of 42 coded compounds in the Salmonella/microsome assay. In: DeSerres FJ, Ashby J, eds. Evaluation of short-term tests for carcinogens. Report of the International ColLabourative Program. New York, NY, Elsevier, pp. 280-284 (Progress in Mutation Research, Vol. 1).
・Gatehouse D (1981) Mutagenic activity of 42 coded compounds in the "microtiter" fluctuation test. In: DeSerres FJ, Ashby J, eds. Evaluation of short-term tests for carcinogens. Report of the International ColLabourative Program. New York, NY, Elsevier, pp. 376-386 (Progress in Mutation Research, Vol. 1).
・Green NR, Savage JR (1978) Screening of safrole, eugenol, their ninhydrin positive metabolites and selected secondary amines for potential mutagenicity. Mutation research, 57(2): 115?121.
・Hubbard SA, Green MHL, Bridges BA, Wain AJ, Bridges JW (1981) Fluctuation test with S9 and hepatocyte activation. In: DeSerres FJ, Ashby J, eds. Evaluation of short-term tests for carcinogens. Report of the International ColLabourative Program. New York, NY, Elsevier, pp. 361-370 (Progress in Mutation Research, Vol. 1).
・Ichinotsubo D, Mower H, Mandel M (1981) Mutagen testing of a series of paired compounds with the Ames Salmonella testing system. In: DeSerres FJ, Ashby J, eds. Evaluation of short-term tests for carcinogens. Report of the International ColLabourative Program. New York, NY, Elsevier, pp. 298-301 (Progress in Mutation Research, Vol. 1).
・Ito N (1982) Unscheduled DNA synthesis induced by chemical carcinogens in primary cultures of adult rat hepatocytes. Mie medical journal, 32(1):53?60.
・Jotz MM, Mitchell AD (1981) Effects of 20 coded chemicals on the forward mutation frequency at the thymidine kinase locus in L5178Y mouse lymphoma cells. In: DeSerres FJ, Ashby J, eds. Evaluation of short-term tests for carcinogens. Report of the International ColLabourative Program. New York, NY, Elsevier, pp. 580-593 (Progress in Mutation Research, Vol. 1).
・Kirkhart B (1981) Micronucleus test on 21 compounds. In: DeSerres FJ, Ashby J, eds. Evaluation of short-term tests for carcinogens. Report of the International ColLabourative Program. New York, NY, Elsevier, pp. 698?704 (Progress in Mutation Research, Vol. 1).
・Klaunig JE, Goldblatt PJ, Hinton DE, Lipsky MM, Trump BF (1984) Carcinogen induced unscheduled DNA synthesis in mouse hepatocytes. Toxicologic pathology, 12(2): 119?125.
・Koudela K, Spazier K (1979) [Effect of dimethylformamide on human peripheral lymphocytes.] Ceskoslovenska Hygiena, 24:432-436 (in Czechoslovakian with English abstract).
・Lewis SC, Rinehart WE, Schroeder RE, Thackara JW (1979) Dominant lethal mutagenic bioassay of dimethyl formamide (DMF). Environmental mutagenesis, 1: 166 (Abstract Ea-7).
・MacDonald DJ (1981) Salmonella/microsome tests on 42 coded chemicals. In: DeSerres FJ, Ashby J, eds. Evaluation of short-term tests for carcinogens. Report of the International ColLabourative Program. New York, NY, Elsevier, pp. 285-297 (Progress in Mutation Research, Vol. 1).
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●Top Page　（トップページ）
●Abbreviation 　（省略記号）　
●Mutagenicity　（変異原性）
●Test Systems　(試験法の種類）
●Technical Problems　（技術的問題点）
●List of　Compounds（化合物リスト）
●Evaluation of Results　（試験結果の評価）