E-3

Group E-3 化学構造　(Chemical Structure)

● Ethylamine （エチラミン）
　 CAS：75-04-7　　Industrial /Solvent　　MW: 45.08　

AM Sal. Max (?) □ 1, 2)

SCE V79 Min (?) ○ 3)

１）Owais WM., et al.: Mutation res., 118, 229-239 (1983)
2) Mortelmans K., et al.: Environ. Mutagen, 8, 229-239 (1983)
3) Spelt G., et al., Mutation Res., 78, 267-272 (1950)
　　　
US-NTP Genotoxicity Screening：
○ Ames Test：　□

● p-Ethyl aniline （p-エチルアニリン）
　　　589-16-2　　laboratory 　　 121.18

CA CHL/IU Min ( 0.031 mg/ml, +S9), 3-21h, D20=0.04; TR=450 ◎ 1)

1) Ishidate MJr.(Ed.): Data Book, Chromosomal Aberration Test In Vitro: LIC/Tokyo, Elsevier/Amsterdam (1988)

● N-Ehylaniline　（N-エチルアニリン）
　　　 103-69-5　Industry　 121.20

AM Sal./ E. coli Max ( 2.5 mg/plate, ±S9) □ 1)

CA CHL/IU Min ( 1.1 mg/ml, -S9), -S9 (Poly also slighly) ○ 1)

1) Ministry of Health, Labour & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 3 (1996) (Tables in English)

● 2-Ethylanthraquinone　（2-エチルアントラキノン）
　　　 84-51-5 Industry　 236.27

AM Sal./E. coli Max ( 5.0 mg/plate, ±S9) □ 1)

CA CHL/IU Max ( 1.362 mg/ml, +S9), 6-18h (Poly; slightly) △ 1)

1) Ministry of Health, Labour & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals,Vol. 8 (1) (2001) (Tables in English)

● Ethylbenzene （エチルベンゼン）(Phenylethane)
　　　 100-41-4　Industry　 106.17

AM Sal./E. coli Max ( 0.5 mg/plate, ±S9) □ 1)

AM Sal. Max ( 0.2 mg/plate, ±S9) □ 2)

AM Sal. Max ( 2 mg/plate, ±S9) □ 3)

AM E. coli Max ( 0.5 mg/plate, ±S9) □ 3)

MY S. serev. Max ( 5 mg/ml, ±S9) □ 3)

MLA L5178Y Max ( 80 μg/ml, -S9) □ 4)

CA Rat hepatocytes Max ( 0.1 mg/ml, ±S9) □ 3)

CA CHO Max ( 0.125 mg/ml, ±S9) □ 5)

CA CHL/IU Max ( 2.0 mg/ml, ±S9), 6-18h □ 6)

MN Syr. hamsters Min ( 0.2 mg/ml, -S9), for 24h ○ 7)

SCE CHO Max ( 0.15 mg/ml, ±S9) □ 5)

CT Syr. hamster Min ( 2 mg/ml, for 7 days) ○ 8)

MNv Mice, BM Max ( 650 mg/kg) ip □ 9)

MNv Mice, Peri. lym. Max ( 1000 ppm) ih, 6h/d, for 13w □ 5)

1) Ishidate MJr. (Ed.) Data Book of Mutagencicity Tests on Chemicals in Bacteria, LIC/Tokyo (1991) (Tables in English)
2) Florin I., et al., Toxicol., 15, 219-232 (1980)
3) Dean BJ., et al., Mutation Res., 153, 57-77 (1985)
4) McGregor DB., et al., Envron. Mol. Mutagen., 12, 85-154 (1988)
5) US NTP, Technic. Rep., Ser. No. 466, NIH. No.99-3956 (1999)
6) Sofuni T (Ed.) Data Book of Chromosomal Aberration Tests in vitro, LIC/Tokyo (1998) (Tables in English)
7) Gibson DP., et al., Mutation Res., 392, 61-70 (1997)
8) Kerckaert GA., et al., Environ. Health. Perspect., 104 (Suppl. 5), 1075-1084 (1996)
9) Mohtashamipur E., et al., Arch Toxicol., 58, 106-109 (1985)

● N-Ethyl-N-(benzoylaminomethyl) nitrosamine （N-エチル-N-(ベンゾイルアミノメチル)ニトロサン）
　　59665-03-1　　　laboratory 　 207.23

CA CHL/IU Max ( 0.50 mg/ml, -S9), 24, 48h; (No data for +S9) □ 1)

1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998) (Tables in English)

● 4-Ethylbiphenyl （4-エチルビフェニール）
　　　 5707-44-8 　Industry　 182.27

AM Sal./E. coli Max ( 0.074 mg/plate, ±S9) □ 1)

CA CHL/IU Max ( 5.0 mg/ml, ±S9), 6-18h □ 1)

1) Ministry of Health, Labour & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 7 (1999) (Tables in English)

● Ethylbromide　　（臭化エチル）　
　　　74-96-4　　Industrial /Solvent　　 108.98

AM E. coli Min (?) ○ 1)

AM Sal. Max (? □ 1)

AM Sal. Min (?) ○ 2,3)

CA CHO Max (?) □ 4)

SCE CHO Min (?) ○ 4)

１）Simmon VF. & Poirier LA.: Proc. Am. Assoc. Cancer Res., 17, 85 (1976)
2) Haworth S., et al.: Environ. Mutagen., 5 (suppl. 1), 3-142 (1983)
3) Zeiger E., et al.: Environ. Mol. Mutagen., 19 (Suppl. 21), 2-141 (1992)
4) Loveday KS., et al.: Environ. Mol. Mutagen., 13, 60-94 (1989)

US-NTP Genotoxicity Screening：
○ Ames Test：　○
○ CA Test with CHO Cells： □
○ SCE Test with CHO Cells：　○
　　
IARC Carcinogenicity Criteria:
Group 3 （Not classifiable as to carcinogenicity to human）

● Ethyl bromoacetate (Bromoacetic acid)
　　　　 105-36-2　　Industry　　 167.00　

AM Sal./E. coli Min ( 0.0781 mg/plate, +S9); spa= 9180 (TA104) ○ 1)

CA CHL/IU Max ( 0.0004 mg/ml, -S9), 6h; △ 2)

1) Ministry of Labour, Japan, Mutagenicity Test Data of Exist. Chem. Subst., JETOC (Ed.),Suppl 2, pp. 66 (2000) (Tables in English)
1) Ministry of Labour, Japan, Mutagenicity Test Data of Exist. Chem. Subst., JETOC (Ed.),Suppl 2., pp. 244 (2000) (Tables in English

● Ethyl 3-bromopropionate 　(Ethyl β-bromopropionate)
　　　　 539-74-2　　Industry　　 181.0　

CA CHL/IU Min ( 0.09 mg/ml, -S9), 24h; D20=0.078 ○ 1)

1) Ministry of Labor, Japan, Mutagenicity Test Data of Exist. Chem. Subst., JETOC (Ed.), pp. 448 (1996) (Tables in English)

● Ethyl butyrate （酪酸エチル）
　　　　 105-54-5　　Food 　　 116.16　

AM Sal Max ( 5.0 mg/plate, ±S9) □ 1)

CA CHL/IU Max ( 2.0 mg/ml, -S9), 24, 48h □ 2)

1) Ishidate MJr. (Ed.) Data Book of Mutagencicity Tests on Chemicals in Bacteria, LIC/Tokyo (1991)(Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998) (Tables in English)

● 2-Ethylbutyric acid　（ 2-エチル酪酸）　　　
　　　88-09-5　 Food 　 116.16

AM Sal./E. coli Max ( 5.0 mg/plate, ±S9) □ 1)

CA CHL/IU Min ( 1.2 mg/ml, -S9), 24h ○ 1)

1) Ministry of Health, Labor & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 9 (2002) (Tables in English)

● Ethyl capronate （カプロン酸エチル）
　　　 123-66-0　　Food 　　　 144.22

AM Sal Max ( 5.0 mg/plate, ±S9) □ 1)

CA CHL/IU Max ( 2.0 mg/ml, -S9), 24, 48h (No data for +S9): □ 2)

1) Ishidate MJr. (Ed.) Data Book of Mutagencicity Tests on Chemicals in Bacteria, LIC/Tokyo (1991)(Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998)

● Ethyl caprylate　（カプリル酸エチル）
　　　 106-32-1 　　Food /Industry　　 172.27

AM Sal./E. coli Max ( 5.0 mg/plate, ±S9) □ 1)

CA CHL/IU Max ( 2.0 mg/ml, -S9), 24, 48h 　(No data for +S9): □ 2)

1) Ishidate MJr. (Ed.) Data Book of Mutagencicity Tests on Chemicals in Bacteria, LIC/Tokyo (1991)(Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998) (Tables in English)

● N-Ethyl-N-( 3-carbazole-3-carbaldehyde　
　　　7570-45-8　　Industry 223

CA CHL/IU Min ( 0.12 mg/ml, +S9), 6-18h; D20=0.21; TR=72 ○ 1)

1) Ministry of Labor, Japan, Mutagenicity Test Data of Exist. Chem. Subst., JETOC (Ed.), pp. 494 (1996) (Tables in English)

● N-Ethyl-N-( 3-carboxypropyl ) nitrosamine 　
　　　54897-63-1　　Laboratory　　 160.17

AM Sal Min (?) ○ 1)

CA CHL/IU Max ( 1.0 mg/ml, -S9), 24, 48h 　(No data for +S9): □ 2)

1) Natl. Inst. Hygien. Sci., Tokyo (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998) (Tables in English)

● Ethyl chloride （クロルエチル） (Chloroethane)
　　 75-00-3　　Industry 　　 64.52

AM Sal. Min (?) ○ 1-3)

AM Sal/E..coli Min ( 1.0 %), +S9 ): spa=1.0%　(Vapor) ○ 5)

DNA Hepatocytes Max (?) □ 3)

SM CHO Min ( 2.3 mg/ml), ±S9 ○ 6)

UDSv Mice Max ( 25,000 ppm, 6h/d, for 3d.), ih □ 6)

MNv Mice Max ( 25,000 ppm, 6h/d, for 3d.), ih □ 1, 6)

CT BALB/c-3T3 Max (?) □ 4,)

1) NTP: Technical Report 346, DHHS (NIH) Pub. No. 90-2801, NTP, Research Triangle Park, NC (1989)
2) Riccio E., et al.: Environ. Mutaagen, 5, 472 (1983)
3) Milman H., et al.: Ann. N.Y. Acad. Sci., 534, 521-530 (1988)
4) Tu AS., et al.: Cancer Lett., 28, 85-92 (1985)
5) Minstry of Labor, Japan, Mutagenicity Test Data of Exist. Chem. Subst., JETOC (Ed.), Suppl. 2, p. 17 (2000) (Taables in English)
6) Ebert R., Mutation Res., 322, 33-44 (1994)
　　
USA-NTP Genotoxicity Screening :
○　Ames Test:　○
○　Mouse Lymphoma Assay: ○
○　CA Test　with CHO cells: □
○　SCE test with CHO cells: △l

ＩＡＲＣ Criteria for Carcinogenicity :
　Group 3 (Not classibiable as to carcinogenicity to humans)

● Ethyl cinnamate （ケイ皮酸エチル）
　　103-36-6　 Food Industry 　　 176.21

AM Sal Max ( 2.0 mg/palate, ±S9)　 □ 1)

CA CHL/IU Max ( 0.063 mg/ml, -S9), 24, 48h (with Poly) ;
(No data for +S9) □ 1)

1) Ishidate MJr. (Ed.) Data Book of Mutagencicity Tests on Chemicals in Bacteria, LIC/Tokyo (1991)(Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998) (Tables in English)

●Top Page　（トップページ）

●Abbreviation 　（省略記号）　

●Mutagenicity Testing　（変異原性試験）

●Test Systems　(試験法の種類）

●Technical Problems　（技術的問題点）

●List of　Compounds（化合物リスト）

●Evaluation of Results　（試験結果の評価）

AM	Sal./ E. coli	Max ( 2.5 mg/plate, ±S9)	□	1)
CA	CHL/IU	Min ( 1.1 mg/ml, -S9), -S9 (Poly also slighly)	○	1)

AM	Sal./E. coli	Max ( 5.0 mg/plate, ±S9)	□	1)
CA	CHL/IU	Max ( 1.362 mg/ml, +S9), 6-18h (Poly; slightly)	△	1)

AM	Sal./E. coli	Max ( 0.5 mg/plate, ±S9)	□	1)
AM	Sal.	Max ( 0.2 mg/plate, ±S9)	□	2)
AM	Sal.	Max ( 2 mg/plate, ±S9)	□	3)
AM	E. coli	Max ( 0.5 mg/plate, ±S9)	□	3)
MY	S. serev.	Max ( 5 mg/ml, ±S9)	□	3)
MLA	L5178Y	Max ( 80 μg/ml, -S9)	□	4)
CA	Rat hepatocytes	Max ( 0.1 mg/ml, ±S9)	□	3)
CA	CHO	Max ( 0.125 mg/ml, ±S9)	□	5)
CA	CHL/IU	Max ( 2.0 mg/ml, ±S9), 6-18h	□	6)
MN	Syr. hamsters	Min ( 0.2 mg/ml, -S9), for 24h	○	7)
SCE	CHO	Max ( 0.15 mg/ml, ±S9)	□	5)
CT	Syr. hamster	Min ( 2 mg/ml, for 7 days)	○	8)
MNv	Mice, BM	Max ( 650 mg/kg) ip	□	9)
MNv	Mice, Peri. lym.	Max ( 1000 ppm) ih, 6h/d, for 13w	□	5)

AM	Sal./E. coli	Max ( 0.074 mg/plate, ±S9)	□	1)
CA	CHL/IU	Max ( 5.0 mg/ml, ±S9), 6-18h	□	1)

AM	E. coli	Min (?)	○	1)
AM	Sal.	Max (?	□	1)
AM	Sal.	Min (?)	○	2,3)
CA	CHO	Max (?)	□	4)
SCE	CHO	Min (?)	○	4)

AM	Sal./E. coli	Min ( 0.0781 mg/plate, +S9); spa= 9180 (TA104)	○	1)
CA	CHL/IU	Max ( 0.0004 mg/ml, -S9), 6h;	△	2)

AM	Sal	Max ( 5.0 mg/plate, ±S9)	□	1)
CA	CHL/IU	Max ( 2.0 mg/ml, -S9), 24, 48h	□	2)

AM	Sal.	Min (?)	○	1-3)
AM	Sal/E..coli	Min ( 1.0 %), +S9 ): spa=1.0%　(Vapor)	○	5)
DNA	Hepatocytes	Max (?)	□	3)
SM	CHO	Min ( 2.3 mg/ml), ±S9	○	6)
UDSv	Mice	Max ( 25,000 ppm, 6h/d, for 3d.), ih	□	6)
MNv	Mice	Max ( 25,000 ppm, 6h/d, for 3d.), ih	□	1, 6)
CT	BALB/c-3T3	Max (?)	□	4,)

AM	Sal	Max ( 2.0 mg/palate, ±S9)	□	1)
CA	CHL/IU	Max ( 0.063 mg/ml, -S9), 24, 48h (with Poly) ; (No data for +S9)	□	1)