Group G-1

化学構造　(Chemical Structure)

● Gallic acid    (Trihydroxybenzoic acid)  （没食子酸）
　　　CAS： 149-91-7 　Food 　MW: 170.12

CA

CHL/IU

Min ( 0.025 mg/ml, -S9), 24, 48h

△*

1)

                                                                    * Possibly caused under the low pH condition　(pH:4.5-5.0)
1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in  English)

● Garlic oil 　（ニンニク油）
　　 8000-78-0　 　Food/Natural 　

AM	Sal	Max ( 2 mg/plate,±S9)	□	1)
CA	CHL/IU	Min ( 0.015 mg/ml, -S9), 48h, Poly:(No deta for+S9)	○*	2)
MNv	Mice	Max ( 200 mg/kg, ip), 24h	□	3)

                                                                * No structural aberrations, but polyploid cells were induced. (47%)
1) Hachiya N et al., Toxicol. Forum., 8, 91-105 (1985)(in Japanese)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)
3） Ishidate MJr et al., Toxicol. Forum., 9, 628-633 (1986)

● Gasoline 　（ガソリン）
　　　 8006-61-9　 　Specific Gravity: 0.72-0.76 (60ﾟF)

AM	Sal	Max (?)	□	1)
MLA	L5178Y	Max (?)	□	1)
DLv	Mice	Max (?)	□	1)
CA	Mice/BM	Max (?)	□	1)
UDS	Mice/RATs	Max (?)	□	2)
UDS	Mice/Liver	Min (?)	○	3)

1) ACGIH document (1997)
2) Loury DJ, et al,: Toxicol. Appl. Pharmacol., 85, 11-23 (1986)
3) Loury DJ, et al,: Toxicol. Appl. Pharmacol., 87, 127-140 (1987)

IARC Carcinogenicity Criteria:
Group 2B (Possibly carcinogenic in humans)

● Geosmin （ゲオスミン）
　　19700-21-1　Industry 　182.31

AM	Sal	Max ( 0.1 mg/plate, ±S9)	□	1)
CA	CHL/IU	Max ( 0.15 mg/ml, ±S9), 6-18h	□	2)

1) Ishidate MJr (Ed.), Data Book of Mutagenicity Tests on Chemicals in Bacteria, LIC/Tokyo (1991) (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)

● Geraniol （ゲラニオール）
　　　 106-24-1 Food 　154.25

AM	Sal	Max ( 0.2 mg/plate, ±S9))	□	1)
CA	CHL/IU	Max ( 0.125 mg/ml, -S9）, 24, 48h, (No data for +S9)	□	2)

1) Ishidate MJr (Ed.), Data Book of Mutagenicity Tests on Chemicals in Bacteria, LIC/Tokyo (1991) (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)

● Ginger oil 　（ショウガ油）
　　 8007-08-7　　Food/Natural 　　

AM	Sal	Max ( 2μｌ/plate, ±S9)	□	1)
CA	CHL/IU	Min ( 0.06 mg/ml, -S9), 24, 48h, :(No deta for+S9)	□	2)
MNv	Mice	Max ( 200 mg/kg, ip), 24h	□	3)

1) Hachiya N et al., Toxicol. Forum., 8, 91-105 (1985)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)
3） Ishidate MJr et al., Toxicol. Forum., 9, 628-633 (1986)

● Glibenclamide （グリベンクラミド）
　　　10238-21-8　　Medicine 　 494.01

AM	Sal	Max (?)	□	1)
CA	CHL/IU	Max ( 0.125 mg/ml, -S9）, 24, 48h (No data for +S9)	□	2)

1) Natl. Inst. Hygien. Sci., Tokyo (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998)