|@@No adequate data were available on the genetic and related effects
of heptachlor in humans.
@@Heptachlor did not induce DL mutation in mice. It induced UDS in human fibroblast cultures but did not induce repair synthesis in cultured rodent cells. It inhibited intercellular communication in rodent cell systems; it was not mutagenic to cultured rat liver cells. It did not induce SLRL mutaion in Drosophila or gene conversion in yeast. It was mutagenc to plants. It was not mutagenic
to bacteria, but in one study, positive results were reported for technical-grade
but not commercial -grade heptachlor. It did not produce breakage of plasmid
DNA. (IARC Monographs, 5, 173; 20,129)