@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@ @@@
Group A-8 ‰»Šw\‘’@(Chemical Structure)  
œ N-Amylurea iƒAƒ~ƒ‹”A‘fj
@
CAS: 38869-91-9@@Laboratory@@MW: 130.22
AM Sal. Max ( 5.0 mg/plate, }S9
 
1)
CA CHL/IU Max ( 2.0 mg/ml, -S9), 24-48h
 
2)

1) Ishidatae MJr & Odashima S: : Mutation Res., 48, 337-354 (1977)
2) Sofuni T (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998j (Tables in English)


œ Amylurethane
iƒAƒ~ƒ‹ƒEƒŒƒ^ƒ“j
@
7451-46-9@@Laboratory@159.23

@@AM@ Sal. Max (?)
 
1)
@CA CHL/IU Max ( 0.25 mg/ml, -S9), 24-48h
 
2)
1) Ishidatae MJr & Odashima S: : Mutation Res., 48, 337-354 (1977)
2) Sofuni T.(Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998j (Tables in English)
œ Ancymidol iƒAƒ“ƒVƒ~ƒh[ƒ‹j
@
12771-68-5@@Pesticide@258.3

AM Sal. Max ( 5.0 mg/plate, }S9)
 
1)
CA CHL/IU Max ( 1.25 mg/ml, -S9), 6-18h
 
1)
UDS ? Max (?)
 
1)
MLA ? Max (?)
 
1)
SCEv ? Max (?)
 
1)
1) Takeda Pharmaceut. Co., Ltd.: J. Pesticide Sci., 17, S151-S154 (1992)
œ Aniline and homologues iƒAƒjƒŠƒ“j (Aminobenzene, Phenylamine)
@
62-53-3@@Industrial /Fertilizer@@93.12@
AM Sal. Max ( 5 mg/ml, }S9)
 
1)
AM Sal. Max ( 6.6 mg/plate, }S9)   10)
SLRL Drosophila Max ( 0.6 mg/ml)
 
2)
CA CHL/IU Min ( 1.0 mg/ml, }S9), 3-21h; D20= 1.3; TR= 24)
›
3)
CA CHO Min ( 0.5 mg/ml, +S9) › 13)
SCE Don Max( 5 x 10-3 M)
 
4)
SCE Human LY Max ( 0.129 mg/ml, }S9)
 
5)
SCE CHO Min ( 0.5 mg/ml, -S9) › 13)
MLA TK-locus Max ( 0.6 mg/ml, -S9)
 
6)
MLA L5178Y/TK Min ( 0.8 ƒΚg/ml, }S9) › 11)
MLA L5178Y/TK Min ( 2.0 mg/ml, }S9) › 12)
UDS Rat Primary Hepatocytes Max ( 0.09 mg/ml, -S9)
 
7)
UDS Human Ly Max ( 1.0 mM)   14)
MNv Mice Max( 0.25 mg/kg)
 
8)
MNv Mice, BM Min ( 380 mg/kg, ip) › 15)
MNv Rats, BM Min ( 287 mg/kg, or) › 16)
CT BALB/C3T3 Min ( 0.5ƒΚg/ml, -S9)
›
9)
DNAv Mice, Kidney Min ( 300 mg/kg, ip) › 17)
1)@Dunkel VC, et al.,: Environ. Mol. Mutagen., 7 (Suppl. 5), 1-248 (1985)
2)@Yoon JS, et al.: Environ. Mol. Mutagen., 7, 349-367 (1985)
3)@Ishidate MJr(Ed.): Data Book, Chromosomal Aberration Test In Vitro, LIC, Tokyo/ Elsevier, Amsterdam (1988)
4)@Abe S & Sasaki M: J. Natl Cancer Inst., 58, 1635-1641 (1977)
5)@Takehisa S & Kanaya N: Mutation Res., 101, 165-172 (1982)
6)@Amacher DE & Paillet SC: Mutation Res., 78, 279-288 (1980)
7)@Williams GM: Natl Cancer Inst. Monogr., 58, 237-242 (1981)
8)@Harper BL, et al.: Proc. Natl Acad. Sci., USA, 82, 6672-6676 (1984)
9)@Dunkel V, et al.: J. Natl Cancer Inst., 67, 1303-1315 (1981)
10) Haworth S.,et al., Environ Mutagen.,Suppl.1, 3-143 (1983)
11) Mitchell AD. et al., Environ Mutagen.,Suppl.13, 37-101 (1988)
12) McGregor DB., et al., Environ Mol. Mutagen,17, 196-219 (1991)
13) Galloway SM., et al., Environ Mol. Mutagen,10, 1-175 (1987)
14) Butterworth BE., et al.,Cancer Res., 49, 1075-1084 (1989)
15) Ashby J, et al., Mutation Res., 263, 115-117 (1991)
16) George E, et al., Carcinogenesis, 11, 1551-1555 (1990)
17) Cesavone CF et al., Arch Toxicol., 5,, 355-359 (1982)

US-NTP Genotoxicity ScreeningF
›@Ames Test:@ 
›@CA Test:@@
›
›@SCETest:@@
›
›@Drosophila (SLRL)Test:@
 
›@MLA Test:@@
›
œ Aniline-HCl@iƒAƒjƒŠƒ“‰–Ž_‰–j
@
142-04-1@@Industrial /Dye@@@129.50

AM Sal. Max (5.0 mg/plate, }S9)
 
1)
CA CHL/IU Max (0.25 mg/ml, -S9), 24-48h
 
2)
1) Ishidatae MJr (Ed): Data Book for Mutagenicity in Bacteria, LIC/Tokyo (1991) (Tables in English)
2) Sofuni T.(Ed.): Data Book of Chromosome Aberration Test In Vitro LIC, Tokyo (1998j (Tables in English)

œ p-Anisaldehyde@ip -ƒAƒjƒXƒAƒ‹ƒfƒqƒhj(4-Methoxybenzaldehyde)
@@
@123-11-5@@@Industrial /Food@@136.15
AM Sal/E.coli Max (10.0 mg/plate, }S9)
 
1,3)
CA CHL/IU Max (0.5 mg/ml, -S9), 24-48h
 
2)
1) Ishidatae MJr (Ed): Data Book for Mutagenicity in Bacteria, LIC/Tokyo (1991) (Tables in English)
2) Sofuni T (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998j (Tables in English)
3) Ministry of Labour, Japan; Mutagen. Test Data of Exist. Chem. Subst. JETOC (Ed.) (1996) (Tables in English
)

œ Anisidine (o-, p-isomers) iƒAƒjƒVƒfƒBƒ“j
@ 
29191-52-4 @@ Industrial /Intermediate 123.15
AM E.coli (p-) Min ( 5.0 ƒΚg/plate, -S9); Spe=23.0 › 1)
CA CHL/IU (o-) Min ( 0.125 mg/ml, -S9), 24-48h; D20= 0.16; TR= 220
(p-) Min ( 0025mg/ml, +S9), 6-18h; D20= 0.009; TR= 2200
›


2, 3)
1) Ministry of Labour, Japan; Mutagen. Test Data of Exist. Chem. Subst. JETOC (Ed.) (1996) (Tables in English)
2) Ministry of Labour, Japan; Mutagen. Test Data of Exist. Chem. Subst. JETOC (Ed.) Suppl. (1997) (Tables in English)
3) Sofuni T (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998j (Tables in English)

US-NTP Genotoxicity ScreeningF
›@Ames Test:@›
›@CA Test:@@
›
›@SCETest:@@
›
›@Drosophila (SLRL)Test:@
 
›@MLA Test:@@
›

œ m-Anisidine im-ƒAƒjƒVƒfƒBƒ“j
@  
536-90-3 @@Industrial@@123.15
CA CHL/IU Min ( 0.5 mg/ml, -S9), 24-48h; D20= 0.63; TR= 21
›
1)
1) Sofuni T (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998j (Tables in English)

œ Annatto potassium salt
(1.05% aqueous solution) (ƒAƒiƒg[ƒJƒŠƒEƒ€‰–j
@@@
Food@@
CA CHL/IU Max (.25 mg/ml, -S9), 24-48h
 
1)
1) Sofuni T (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998j (Tables in English)
œTop Page@iƒgƒbƒvƒy[ƒWj
œAbbreviation @iΘ—ͺ‹L†j@
œMutagenicity i•ΟˆΩŒ΄«j
œTest Systems@(ŽŽŒ±–@‚ΜŽν—ށj
œTechnical Problems@i‹Zp“I–β‘θ“_j
œList of@Compoundsi‰»‡•¨ƒŠƒXƒgj
œEvaluation of Results@iŽŽŒ±Œ‹‰Κ‚Μ•]‰Ώj