Group C-11 ‰»Šw\‘’@(Chemical Structure)  
œ Copper (quinolin-8-olato) (ƒRƒbƒp[j@@@@ @@
@@
 10380-28-6@ Pesticide@ MW: 353.87
REC B. subtilis Max ( 50 ƒΚ‚‡/disk)
 
1)
AM Sal. Max ( 10 ƒΚ‚‡/plate)
 
1)
CA CHL/IU Max ( 0.136 m‚‡/ml, -S9)
 
1)
MNv Rat/CFY Max ( 5.6 g/kg x 2)
 
1)
1) Nihon Noyaku Co. Ltd., et al: J. Pesticide Sci., 16, 563-567 (1991)

œ Creatinine @iƒNƒŒƒAƒ`ƒjƒ“j@@ @@
@@@
60-27-5 @Laboratory@ 113.12
CA CHL/IU Min (10 m‚‡/ml, -S9), 24h; D20= 8.0 mg/ml; TR= 1.5
›
1)
1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998j (Tables in English)

œ p-Cresidine@ip-ƒNƒŒƒVƒWƒ“j (2-Methoxy-5-methylaniline
@@@ 120-71-8 @Industry@ 137.18
AM Sal./E. coli Min ( 0.156 mg/plate, +S9) spa= 1040 (TA100) › 1)
CA CHL/IU Min ( 0.10 mg/ml, -S9), 24h; D20= 0.20; TR= 98 › 2)
MNv CD-1 mice Max ( 2 ‚‡/kg x 2 ,po), 24h;
 
3)
1) Ministry of Labour, Japan; Mutagen, Test Data of Exist. Chem.. Subst., JETOC (Ed.) Suppl. pp. 217 (1997) (Tables in English)
2) Ministry of Labour, Japan; Mutagen, Test Data of Exist. Chem.. Subst., JETOC (Ed.), Suppl. 3,  pp. 222 (2005) (Tables in English)
3) MoritaT.,et al., Mutation Res., 389, 3-122 (1997)

œ m-Cresol @(3-Methylphenol) im-ƒNƒŒƒ][ƒ‹G@ ƒqƒhƒƒLƒVƒgƒ‹ƒGƒ“;@@ƒNƒŒƒ][ƒ‹Ž_j
@@@
108-39-4
@@Industry @ 108.14
AM Sal./ E. coli Max ( 1.25 mg/plate, }S9)
 
1-3)
MLA L5178Y Max ( 0.5 mg/ml, }S9)   4)
CA CHO Max (?), }S9)   4)
UDS Rat hepatocytes Max ( 0.01 mg/ml, -S9)   4)
SCE Human Fb.. Max (?), -S9)   5)
SCE Human Ly. Max (?), -S9)   6)
CT Mouse 3T3 Max ( 72 nl/ml, }S9)   7)
DNA SV40 induction Min (?,), -S9) ›w 8)
DNA CH cells Max (?,), -S9)   9)
SCEv Mice, BM/Liver Max ( 200 mg/kg, ip)   4)
1) Ministry of Labor, Japan; Mutagen, Test Data of Exist. Chem.. Subst., JETOC (Ed.) Suppl. (1997)  (Tables in English)
2) Douglas GR., et al., Water Chorinate. Environ. Impact. Health Effects, 3, 865-880 (1980)
3) Haworth S., et al., Environ. Mutagen., 1, 3-142 (1983)
4) Hazleton labs. Repl submitet to US-EPA (unpublished data) (1989)
5) Cheng M & Kligerman AP, Mutation Res., 137, 51-55 (1984)
6) Jansson T., et al., Mutation Res., 169,, 129-139 (1986)
7) Hazleton labs. Repl submitet to US-EPA (unpublished data) (1988)
8) Moor SP & Cochill TP, Prog. Nucleic Acid, Res. Mol. Biolol., 29, 149-153 (1983)
9) Pool BL., et al., Mutation Res., 213, 61-72 (1989)
10) UIS-NTP Reprot., 9, 1990/1991 (1990/1991)
11) Cheng M & Kligerman AP, Mutation Res., 137, 51-55 (1984)

œ Crotonaldehyde (2-Butenal) iƒNƒƒgƒ“ƒAƒ‹ƒfƒqƒhj
@@@
4170-30-3 @Industry @ 70.09
CA CHL/IU Min ( 0.003 m‚‡/ml, -S9), 24;Poly also; D20=0.0025 TR=400

1)
1) Ministry of Labour, Japan; Mutagen, Test Data of Exist. Chem.. Subst., JETOC (Ed.) (1996)

œ Crotonaldehyde (trans-form) iƒNƒƒgƒ“ƒAƒ‹ƒfƒqƒh ƒgƒ‰ƒ“ƒX‘́j
@@@
123-73-9@ Industry @ 70.09
AM Sal./ E. coli Min ( 0.0781 mg/plate, -S9); Spa=2440 (TA100)

1)
1) Ministry of Labor, Japan; Mutagen, Test Data of Exist. Chem.. Subst., JETOC (Ed.) (1996) (Tables in English)

œ Cucumopine iƒNƒNƒ‚ƒpƒCƒ“j
@@@
110342-24-0 @Natural @ 283.24
CA CHL/IU Min ( 5.0 m‚‡/ml, -S9), 48h; D20= 7.9; TR= 1.0
Poly ( 0.5 mg/ml, -S9), 48h; D
20= 0.10
›
1)
1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998j (Tables in English)

œ Cumene iƒNƒƒ“ji2-phenyl-propane; isopropylbenzene, 1-methylethyl-benzenej
@@ 98-82-8 @Industry @ 120.2
@@@@54724-00-4 @@Food
UDS Rat hepatocytes Min ( 16ƒΚ‚‡/ml j
›
1)
CT BALB/3T3 Min ( 60 ƒΚ‚‡/ml j
›
1)
1) Hazardous Substances Data Bank (HSDB), U.S. Natl Library of Medicine (1998)

yNotez@(Cited from CICADs Documents, 18, 1999)

  In general, negative results have been obtained in a relatively complete battery of in vivo and in vitro mutagenicity tests, including gene mutation, chromosomal aberration, and primary DNA damage (US EPA, 1997). Cumene was tested at concentrations up to 2000 ƒΚg/plate in a Salmonella typhimurium reverse mutation assay (modified Ames test); negative results were observed with and without metabolic activation (Lawlor & Wagner, 1987). Cumene was negative in an Ames assay at concentrations up to 3606 ƒΚg/plate with S. typhimurium strains TA98, TA100, TA1535, and TA1537 (Florin et al., 1980). Cumene also tested negative, with and without metabolic activation, in a set of HGPRT assays (using Chinese hamster ovary cells) at cumene concentrations of 100-125 ƒΚg/ml, at which the relative cloning efficiencies (a measure of cytotoxicity) ranged from 29% to 110% (Gulf Life Sciences Center, 1985a; Yang, 1987). A micronucleus assay performed in mice given up to 1 g cumene/kg body weight by gavage was negative (Gulf Life Sciences Center, 1985b). Micronucleus assays done in Fischer-344 rats, however, gave values that were weakly positive, although little dose-response was seen, and deaths occurred at the highest dose (5 of 10 animals at 2.5 g/kg body weight intraperitoneally; NTP, 1996). The positive control used in the micronucleus tests, cyclophosphamide, produced strong positive responses in all assays.
    Cumene failed to induce significant rates of transformation in BALB/3T3 cells (without activation) at concentrations up to 500 ƒΚg/ml (Putnam, 1987) but tested positive in an earlier cell transformation test also using BALB/3T3 cells, in which an increase in transformations was observed at 60 ƒΚg/ml (Gulf Oil Corp., 1984a). Results from an unscheduled DNA synthesis assay in rat hepatocytes conducted by Gulf Oil Corp. (1984b) indicated positive results at doses of 16 and 32 ƒΚg cumene/ml (with 128 ƒΚg/ml noted as toxic to the hepatocytes). However, apparent technical difficulties with this test (US EPA, 1988) prompted a repeat of the unscheduled DNA synthesis assay in rat hepatocytes, the results of which showed cumene to be clearly negative at doses up to 24 ƒΚg/ml, with doses above 24 ƒΚg/ml noted as being too toxic for evaluation of unscheduled DNA synthesis (Curren, 1987; US EPA, 1988).

References
ECurren RD (1987) Unscheduled DNA synthesis in rat primaryhepatocytes -- test article: Cumene. Bethesda, MD, Microbiological Associates, Inc. Washington, DC, US Environmental Protection Agency, Office of Toxic Substances (Study No. T4786.380005; TSCA section 4 submission 40-8792124).
EFlorin I, Rutberg L, Curvall M, Enzell CR (1980) Screening of tobacco smoke constituents for mutagenicity using the Ames test. Toxicology, 18:219-232.
EGulf Life Sciences Center (1985a) CHO/HGPRT test of cumene. Pittsburgh, PA. Washington, DC, US Environmental Protection Agency, Office of Toxic Substances (Gulf Project No. 84-2128; TSCA section 8(d) submission 878216011).

EGulf Life Sciences Center (1985b) Micronucleus test of cumene. Pittsburgh, PA. Washington, DC, US Environmental Protection Agency, Office of Toxic Substances (Gulf Project No. 84-2129; TSCA section 8(d) submission 878216015).

EGulf Oil Corp. (1984a) Cell transformation test of cumene. Houston, TX. Washington, DC, US Environmental Protection Agency, Office of Toxic Substances (Gulf Project No. 84-2131; TSCA section 8(e) submission 888500694).
EGulf Oil Corp. (1984b) Hepatocyte primary culture/DNA repair test ofcumene. Houston, TX. Washington, DC, US Environmental Protection Agency, Office of Toxic Substances (Gulf Project No. 84-2130; TSCA section 4 submission 888500694).

ELawlor TE, Wagner VO (1987) Salmonella /mammalian-microsomepreincubation in mutagenicity assay (Ames test); test article:Cumene. Bethesda, MD, Microbiological Associates, Inc. Washington, DC, US Environmental Protection Agency, Office of Toxic Substances (Study No. T4786.502009; TSCA section 4 submission 40-8792121).
ENTP (1996) In-vivo cytogenetics testing results for cumene,micronucleus induction results. Available from National Toxicology Program, National Institute for Environmental and Health Sciences, Research Triangle Park, NC.
EPutnam DL (1987) Chromosome aberrations in Chinese hamster ovary(CHO) cells -- test article: Cumene. Bethesda, MD, Microbiological Associates, Inc. Washington, DC, US Environmental Protection Agency, Office of Toxic Substances (Study No. T4786.337012; TSCA section 4 submission 40-8792123).
EUS EPA (1988) Cumene; final test rule. Federal register, 53(144) :28195-28206.
EUS EPA (1997) Integrated Risk Information System (IRIS) online at http://www.epa.gov/iris (including the Toxicological review ofcumene in support of summary IRIS information, National Center for Environmental Assessment, Cincinnati, OH). Washington, DC, US Environmental Protection Agency.
EYang LL (1987) CHO/HGPRT mutation assay; test article: Cumene. Bethesda, MD, Microbiological Associates, Inc. Washington, DC, US Environmental Protection Agency, Office of Toxic Substances (Study No. T4786.332010; TSCA section 4 submission 40-8792124).

œ Curcumine @(ƒNƒ‹ƒNƒ~ƒ“j
@@@
458-37-7 @Natural @ 283.24
AM Sal Max (?)
 
1)
CA CHL/IU Min ( 0.02 m‚‡/ml, -S9), 24-48h; D20= 0.023; TR= 400
›
2)
1) Natl Inst. Hygien. Sci., Tokyo ?
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998j  (Tables in English)

œ Curdlan @iƒJ[ƒhƒ‰ƒ“j
@@@@54724-00-4 @@Food
REC B. subtilis Max ( 2.0 m‚‡/disk)
 
1)
AM Sal. Max ( 3.0 m‚‡/plate)
 
1)
CA CHL/IU Max ( 5.0 m‚‡/ml, }S9)   2)
MN CHL/IU Max ( 5.0 m‚‡/ml, }S9)   3)
1) (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998j  (Tables in English)
3) (?)

œ Cyanazine @(Bladex) iƒOƒ‰ƒƒbƒNƒXj@
@@@
21725-46-2@ @Pesticide@ 240.70
REC B. subtilis Max ( 2.0 m‚‡/disk)
 
1)
AM Sal. Max ( 3.0 m‚‡/plate)
 
1)
HMA  (?) Max (?)
 
1)
DLv Mice Max (?)
 
1)
1) Shell Chem. Co. Ltd., J. Pesticide Sci., 11, 127-130 (1986)

œ Cyanoguanidine (Dicyanodiamide)iƒTƒCƒAƒmƒOƒAƒjƒWƒ“j
@@
461-58-5 @Industry @ 84.08
AM Sal./E.coli Max ( 5.0 mg/plate)
 
1 ,2)
CA CHL/IU Max ( 0.84 m‚‡/ml, }S9), 6-18h
 
1)
1) Ministry of Health, Japan (Ed.): Toxicity Testing Reports of Environ. Chemicals, Vol. 6 (1998)  (Tables in English)
2)  Minstry of Labour, Japan; Mutagen. Test Data of Exist. Chem. Subst., JETOC (Ed.)(1996)  (Tables in English)

œ Cyanopyridine
iƒTƒCƒAƒmƒsƒŠƒWƒ“j
@@
100-54-9 @Industry @ 104.12

AM Sal./E.coli Max ( 5.0 mg/plate, }S9)
 
1)
CA CHL/IU Max ( 5.0 m‚‡/ml, }S9), 6-18h
 
1)
1) Ministry of Health, Japan (Ed.): Toxicity Testing Reports of Environ. Chemicals, Vol.5(1997)  (Tables in English)

œ 2,2'-o-Cyclocytidine -HCl @i‚QC‚Qf|‚O|ƒTƒCƒNƒƒVƒ`ƒWƒ“₯‰–Ž_j
@@@
10212-25-6@ Medicine @ 261.69
CA CHL/IU Min (0.002 m‚‡/ml, -S9), 48h;
D
20= 0.0025 mg/ml; TR= 7000

1)
1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998j  (Tables in English)

œ ƒΐ-Cyclodextrin iƒΐ-ƒTƒCƒNƒƒfƒLƒXƒgƒŠƒ“j
@@  7585-39-9@Food/Natural @@ 1134.99
AM Sal. Max ( 10 mg/plate, }S9)
 
1)
CA CHL/IU Max (4.0 m‚‡/ml, -S9), 24-48h: (No data for +S9)
 
2)
1) Ishidate, MJr. (Ed.) Data Book of Mutagenicity Tests on Chemicals in Bacteria, LIC (1991)  (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998j  (Tables in English)

œ Cyclohexane@iƒTƒCƒNƒƒwƒLƒTƒ“j
@@@
110-82-7@Industry@@ 84.16
AM Sal. Max ( 1.0 m‚‡/plate, }S9)
 
1, 2)
CA CHL/IU Max ( 0.75 m‚‡/ml, -S9), 24-48h:
Max ( 4.0 mg/ml, }S9), 6-18h
 
3)
1) McCann J, et al,: Proc. Natl. Acad. Sci. (USA), 72, 5135-5139 (1975)
2) Ishidate, MJr. (Ed.) Data Book of Mutagenicity Tests on Chemicals in Bacteria, LIC (1991)  (Tables in English)
3) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998j  (Tables in English)
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œAbbreviation @iΘ—ͺ‹L†j@
œMutagenicity @i•ΟˆΩŒ΄«j
œTest Systems@(ŽŽŒ±–@‚ΜŽν—ށj
œTechnical Problems@i‹Zp“I–β‘θ“_j
œList of@Compoundsi‰»‡•¨ƒŠƒXƒg)
œEvaluation of Results@iŽŽŒ±Œ‹‰Κ‚Μ•]‰Ώj

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