Group C-8

化学構造　(Chemical Structure)

● Chloropentabromocyclohexane　（クロロペンタブロモサイクロヘキサン）
　　CAS:　87-84-3　　Industry　 MW: 513.09

AM	Sal./E. coli	Max ( 5.0 mg/plate. ±S9)	□	1)
CA	CHL/IU	Min ( 0.03 mg/ml, -S9), 24h; D20=0.02	○	1)

1) Ministry of Health & Welfare, Japan: Toxic. Test. Rep., Environ. Chem., Vol.4, 77 (1996) (Tables in English)

● Chloropicrin　（クロロピクリン）　　　　 　　
　　　　76-06-2　　 Insecticide/Fungicide　 164.39

AM	Sal..	Min ( 50 μg/plate, -S9)	○	1)
BM	E. coli	Min ( 300 μg/L)	○	1)
CA	Hum. lym.	Min (?)	○	2)
CA	CHO	Min (?)	○	3)
SCE	Hum. lym.	Min ( 8 mg/L)	○	1)
SCE	CHO	Min (?)	○	3)
SLRLv	Drosophila	Min (?)	○	3)

1) Registry of Toxic Effects of Chemical Substances (RTECS), US NIOSH (1998)
2) Hazard. Substances Data Bank (HSDB), US National Library of Medicine (1998)
3) ACGIH (1991)

 US-NTP Genotoxicity Screening：
  ○ Ames Test : ○　
  ○ ＣＡ　Ｔｅｓｔ　ｗｉｔｈ　ＣＨＯ　Ｃｅｌｌｓ: ○　
  ○ SCE Test with CHO Cells:　○
 ○ SLRL Test with Drosophila : △

● 3-Chloropropionic acid  （クロロプロピオン酸）　　　 　　
　　　　76-06-2　　 Industry 　 108.52

AM

Sal/E. coli

Min ( 1.22 μg/plate, ±S9）;  spa= 1.7 x 104

◎

1)

1) Ministry of Labor, Japan; Mutagen. Test Data of Exist. Chem. Subst..; JETOC (Ed.)、Suppl. 3, pp. 167 (2005)   (Tables in English)

● β-Chloroprene （β-クロロプレン）
　　　 126-99-8　 Industry　　 88.54

AM	Sal./E. coli	Min (?)±S9	○	1)
CA	V79	Max (?)	□	2)
SLRL	Drosophila	Min ( 5.7-11.4 mM for 3d)	○	3)
DLv	Rats	Min (?)	○	1)
DLv	Mice	Min ( 0.5-1.0 ppm)	○	4)
CAv	Rat/BM	Min ( 0.04-1.0 ppm)	○	4)

1) Bartsch H., et al.: Arch. Toxicol., 41, 249-277 (1979)
2) Drevon C. & Kuroki T.: Mutation Res., 67, 173-182 (1979)
3) Vogel E.: Mutation Res., 67, 377-381 (1979)
4) Samotskii IV.: Environ. Health. Perspect., 17, 85-93 (1978)

 US-NTP Genotoxicity Screening：
 ○ Ames Test (±S9): 　□

 【Note】 (Cited from IARC Monographs, Suppl., 6 (,1987))

An increaed incidence of CAs was found in the lymphocytes of worders exposed to chloroprene. 　　Chloroprene induced DL mutations in rats and CAs in bone-marrow cells of mice treated in vivo. It induced transformation in one hamster cell line but did not induce mutation in Chinese hamster cells. It induced SLRL mutations in Drosophila and was mutagenic to bacteria.

● Chlorothiazide （クロロチアザイド）
    58-94-6　Medicine　　 295.74 　　　　　　　　　　　　

AM	Sal./E. coli	Min (?)	○	1)
CA	CHL/IU	Max ( 2.0 mg/ml, -S9), 24-48h (No data for +S9)	□	2)

1) Waskell LA; Mutation Res., 57, 141 (1978)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998)   (Tables in English)

● o-Chlorotoluene (1-Chloro-2-methylbenzene）(2-クロロトルエン)
　　 95-49-8　Industry　　 126.59　　　　

AM	Sal./E. coli	Max ( 0.5 mg/plate, ±S9)	□	1)
AM	Sal.	Max ( 1.2 mg/plate, ±S9)	□	2)
MLA	L5178Y	Max ( 90 nl/ml, +S9), for 4h	□	3)
CA	CHO	Max ( 0.09 mg/ml, ±S9), for 10h	□	4)
UM	Sal.	Max ( 100μg/ml, ±S9)	□	5)
CT	Balb/3T3	Max ( 1.5 mg/ml, -S9)	□	6)
CAv	Rats, BM	Max ( 300 mg/kg), or	□	7)

1) Ministry of Labour, Japan; Mutagen. Test Data of Exist. Chem. Subst..; JETOC (Ed.) (1996)   (Tables in English)
2) Brusik DJ., Final Rep. LBI Proj. No. 20988, Litton Bionecs, US EPA OTS 0507442 (1982)
3) Cifone MA & Balinas WV.,Final Rep. LBI Proj. No. 30989, Litton Bionecs, US EPA OTS 0509042 (1985)
4) Galloway SM & Labowitz H., Final Rep. LBI Proj. No. 20970, US EPA OTS0507446 (1982)
5) Ohno Y., et al., Water Sci. Tech., 26, 61-69 (1992)
6) Rundell JO & Mathew EJ., Final Rep. LBI Proj. No. 20992, US EPA OTS0507430 (1983)
7) Cifone MA & Balinas WV.,Final Rep. LBI Proj. No. 22174, Litton Bionecs, US EPA OTS 0507445 (1982)

● p-Chlorotoluene (1-Chloro-4-methylbenzene）(p-クロロトルエン）
　　 106-43-4　Industry　　 126.59　　　　

AM

Sal./E. coli

Max ( 1.25 mg/plate, ±S9)

□

1)

1) Ministry of Labour, Japan; Mutagen. Test Data of Exist. Chem. Subst..; JETOC (Ed.) (1996)   (Tables in English)

● Chlorpromazine-HCl　（クロルプロマジン・塩酸）
　　 69-09-0　Medicine　　 355.32

AM	Sal./E. coli	Max (?)	□	1)
CA	CHL/IU	Max ( 0.0075mg/ml, -S9), 24-48h (No data for +S9)	□	2)
SCE	V79	Min ( 0.001mg/ml)	○	3)

1) Speit G & Vogel W; Mutation Res., 59, 223-229 (1979)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test i In Vitro, LIC, Tokyo (1998)   (Tables in English)

● Chlorpropamide （クロルプロパミド ）(Sulphonylurea)
　　 94-20-2　 Medicine　　 276.75

AM	Sal./E. coli	Max (?)	□	1)
CA	CHL/IU	Min( 1.0 mg/ml, -S9), 48h (No data for +S9); D20= 1.8; TR= 4.0	○	2)
MNv	Mice	Min (?)	○	3)
CAv	Hum. Ly.	Min ( 300 mg/day) for 8h	○	4)

1) Natl Inst. Hygien. Sci., Tokyo (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998)   (Tables in English)
3) (?)
4) Watson WA., et al.; Mutation Res., 38, 71-80 (1976)

● Chlorpyrifos 　(Dursban)　（クロールピリホス）
　　  2921-88-2　 Pesticide　　 530.57

AM	Sal./E. coli	Max (?)	□	1)
CA	CHL/IU	Min ( 0.037 mg/ml, +S9), 3-21h; D20= 0.001; TR= 270	○	2)
MN	Mice	Min (?)	○	3)

1) Natl Inst. Hygien. Sci., Tokyo ?
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998)   (Tables in English)
3) ?

● Chlortetracycline-HCl　（クロールテトラサイクリン-塩酸）
　　64-72-2　 Medicine　　 515.38

AM	Sal./E. coli	Max (?)	□	1)
CA	CHL/IU	Max ( 0.5 mg/ml, -S9), 24-48h (No data for +S9)	□	2)

1) Natl Inst. Hygien. Sci., Tokyo ?
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test in vitro LIC, Tokyo (1998)   (Tables in English)

● Cholecalciferol (Vitamin D3) （ビタミンD3）
　　67-97-0　 Food　 384.64

AM	Sal.	Max ( 50.0 mg/plate, ±S9)	□	1)
CA	CHL/IU	Max ( 0.06 mg/ml, -S9), 24-48h (No data for +S9)	□	2)

1) Ishidate MJr.（Ed.): Data Book of Mutagenicity Tests on Chemicals in Bacteriria, LIC/Tokyo (1991)   (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test in vitro LIC, Tokyo (1998) (Tables in English)

● Choline salt of malec hydrazide （マレイン酸コリン塩）
　　123-33-1　 Pesticide　 215.25

REC	B. subtilis	Max (?)	□	1, 2)
AM	Sal./E. coli	Max (?)	□	1, 2)
CA	CHL/IU	Max (?)	□	1, 2)

1) Nihon Hydrazine Co. Ltd.: J. Pesticide Sci., 12, 771-774 (1987)
2) NIHONN NOHYAKU ZASSI: 12, 771-774 (1987) (in Japanese)