@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@
Group E-2 ‰»Šw\‘’@(Chemical Structure)  

œ Ester gum (AAG) @iƒGƒXƒeƒ‹ƒKƒ€j
@@CAS: 8050-31-5@@ Food/Natural MW:
AM Sal. Max (?)
 
1)
CA CHL/IU Max ( 8.0 mg/ml, -S9), 24, 48h@(No data for + S9)
 
2)
1)@Ishidate MJr (Ed.), Data Book of Mutagenicity Tests on Chemicals in Bacteria, LIC/Japan (1991) (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vtro LIC, Tokyo (1998)  (Tables in English)

œ Ethenzamide @iƒGƒeƒ“ƒUƒ}ƒCƒhG@o - Ethoxybenzamidej
@@@ 938-73-8@@Medicine@@ 165.19
AM Sal. Max (?)
 
1)
CA CHL/IU Min ( 0.5 mg/ml, -S9), 48h (With Poly)@D20= 0.81; TR= 10
›
2)
1) Natl. Inst. Hygien. Sci., Tokyo ?
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vtro LIC, Tokyo (1998)  (Tables in English)

œ Ethidium bromide (Homidium bromide) iƒGƒ`ƒWƒEƒ€ƒuƒƒ}ƒCƒhj
@@ 1239-45-8@ Medicine@ 394.31
AM Sal. Min (?)
›
1)
CA CHL/IU Min ( 0.03 mg/ml, -S9), 24,48h @D20= 0.042; TR= 330

2)
MLA L5178Y Max ( 20 ƒΚg/ml, }S9)   3)
1) Natl. Inst. Hygien. Sci., Tokyo, Japan (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vtro LIC, Tokyo (1998)   (Tables in English)
3) Oberly TJ., et al., Mutation Res., 125, 291-306 (1984)
œ 17-Ethinylestradiol
@ @@57-63-6@@Medicine@ @296.39
AM Sal. Max (?)
 
1)
CA CHL/IU Max ( 0.0037 mg/ml, -S9), 24, 48h (No data for +S9)
 
2)
1) Natl. Inst. Hygien. Sci., Tokyo, Japan (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vtro LIC, Tokyo (1998)   (Tables in English)

œ Ethionamide
iƒGƒ`ƒIƒiƒ}ƒCƒhj
@ @ 536-33-4@Medicine@@ 166.24
AM Sal. Max (?)
 
1)
CA CHL/IU Min ( 0.4 mg/ml, -S9), 48h (No data for +S9): D20= 0.50; TR= 18
›
2)
1) Natl. Inst. Hygien. Sci., Tokyo, Japan (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vtro LIC, Tokyo (1998)   (Tables in English)

œ dl -Ethionine @
idl- ƒGƒ`ƒIƒjƒ“j
@@ 67-24-0@@@ 163.26
AM Sal. Max (?)
 
1)
CA CHL/IU Max ( 8.0 mg/ml, }S9), 48h
 
2)
1) Natl. Inst. Hygien. Sci., Tokyo, Japan (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vtro LIC, Tokyo (1998)   (Tables in English)

œ 4-Ethoxybenzenamine
i4-ƒGƒgƒLƒVƒxƒ“ƒ[ƒiƒ~ƒ“j
@@
156-43-4@Industry@ 137.18
AM Sal. Max (5.0 mg/plate, }S9)
 
1)
CA CHL/IU Min ( 0.02 mg/ml, -S9)
›
1)
MNv Mice/BM Min ( 1.0 g/kg, po), 24h
›
1)
1) Ministry of Health, Labour & Welfare, Japan (Ed): Tox. Test. Rep. of Environ. Chem, Vol. (1994) (Tables in English)

œ Ethoxyethanol@iƒGƒgƒLƒVƒGƒ^ƒm[ƒ‹jiƒGƒ`ƒ‹ƒuƒŠƒRƒ‹G@ƒGƒ`ƒ‹ƒZƒƒ\ƒ‹ƒvG@ƒZƒ‹ƒ\ƒ‹ƒvj@
@@@110-80-5@@Industrial/Solvent @@ 90.12
AM Sal.. Max ( 5.0 mg/plate, }S9)
 
1)
AM Sal.. Max ( 10.0mg/plate, }S9)   2)
AM Sal. Max ( 10.0mg/plate, }S9)   3)
AM E. coli Max (5.0 mg/plate, }S9)   1)
SM CHO Max (42 mg/plate, }S9)   4)
MLA Y1578Y Min ( 4.6 mg/plate,  +S9) ›w 3)
CA CHO Min ( 20 mg/plate,  -S9) › 4)
CA CHO Min ( 9.5 mg/ml, -S9)
›
3)
SCE CHO Min ( 9.5 mg/ml, }S9)
›
3)
SLRLv Drosophila Max ( 50 mg/ml, fed )   5)
SLRLv Drosophila Max ( 50000 ppm, fed )   3)
MNv Mice Max ( 2.1 g/kg, ip )   4)
1) Shimizu H., et al., Jpn J. Indust. Health, 27, 400-419 (1985)
2) Zeiger E., et al., Environ. Mutagen., 7, 213-232 (1985)
3) US-NTP Rep. Series, No. 26, NIH Pub. No. 93-349, PB94118106 (1993)
4) Guzzie PJ., et al., Environ. Mutagen., 8, 33 (1986)
5) Valencia R., et al., Envron. Mutagen., 8, 325-348 (1985)

US-NTP Genotoxicity ScreeningF
› Ames TestF
@ 
› MLA TestF@ 
› CA Test with CHO CellsF ›
› SCE Test with CHO Cells:F ›
›SLRL Test with Drosophila:@ 
@@

œ Ethoxyethyl acetate@(Acetic acid 2-ethoxy ethylester) iƒGƒ`ƒŒƒ“ƒOƒŠƒR[ƒ‹ƒ‚ƒmƒGƒ`ƒ‹ƒAƒZƒe[ƒgG@ƒGƒ`ƒŒƒ“ƒOƒŠƒR[ƒ‹|Ž_ƒ‚ƒmƒGƒXƒeƒ‹G ƒZƒƒ\ƒ‹ƒvƒAƒZƒe[ƒgj
@@
@111-15-9@@Industrial@@ 132.16

AM Sal./E. coli Max ( 5.0 mg/plate, }S9)
 
1)
SM CHO Max ( ? ), }S9)   2)
CA CHO Min ( 4.4 mg/ml, +S9) › 2)
SCE CHO Max ( ? ), }S9)   2)
MNv Mice, BM Max ( ? ), fed)   2)
1) Ministry of Labour, Japan, Mutagenicity Tests of Exist. Chem. Subst., JETOC (Ed.), Suppl. 2, pp. 63 (2000)  (Tables in English)
2) Environ. Mol. Mutagen., 11, Suppl. 11, 97 (1988)

œ 3-Ethoxy
-4-hydroxybenzaldehyde (
Ethyl vanillin)
@@@121-32-4@@Industrial@@ 166.18

AM Sal./ E. coli Max ( 5.0 mg/plate, }S9)
 
1)
1) Ministry of Labour, Japan, Mutagenicity Tests of Exist. Chem. Subst., JETOC (Ed.), Suppl. pp, 161 (1997)(Tables in English)

œ 2-Ethoxynaphthalene (Ethyl 2-naphtyl ether)
@@@
93-18-5@@Industrial@@ 172.23
AM Sal./ E. coli Max ( 1.25 mg/plate, }S9)
 
1)
1) Ministry of Labour, Japan, Mutagenicity Tests of Exist. Chem. Subst., JETOC (Ed.), Suppl. 2, p.p.163 (2000)(Tables in English)

œ Ethychlozate @iƒtƒBƒKƒƒ““ϋάj
@ @@27512-72-7@Plant Growth Agent @ 238.6
REC B. subtilis Max ( 2.0 mg/disk)
 
1)
AM Sal Max ( 5.0 mg/plate, }S9)
 
1)
1) Nissan Kagaku/Fujisawa Yakuhinn Co.Ltd: J. Pesticide Sci., 11, 137-138 (1986) (in Japanese)

œ Ethyl acetate i|Ž_ƒGƒ`ƒ‹j@
@@@141-78-6@ Food/Industry@ 88.11
AM Sal. Max ( 5.0 mg/plate, }S9)
 
1, 2, 3)
CA CHL/IU Min ( 9.0 mg/ml, -S9), 24, 48h (Weak) (No data for +S9)
›
4)
MNv Mice Max ( 200 mg/kg x 4), ip, 24h
 
5)
‚PjZeiger E., et al.: Environ. Mol. Mutagen., 19 (Suppl. 21), 2-141 (1992)
2) Ishidate MJr (Ed.), Data Book of Mutagenicity Tests on Chemicals in Bacteria, LIC/Japan (1991) (Tables in English)
3)
Ministry of Labour, Japan, Mutagenicity Tests of Exist. Chem. Subst., JETOC (Ed.), Suppl.., pp. 164 (1997) (Tables in English)
3) Ishidate MJr.(Ed.): Data Book, Chromosomal Aberration Test:LIC, Tokyo/Elsevier, Amsterdam (1988) (Tables in English)
4) Hayashi M., et al.: Fd Chem. Toxic. 26, 487-500 (1988)@
@

US-NTP Genotoxicity ScreeningF
› Ames TestF@ 
› MLA@TestF@ 
› SCE Test with CHO Cells:F@›
› CA Test with CHO CellsF@ 

œ Ethyl acetoacetate
@@@141-97-9@ Food @ 130.14@@@
AM Sal. Max ( 25.0 mg/plate, }S9)
 
1, 2)
CA CHL/IU Max ( 2.0 mg/ml, -S9), 24, 48h@(No data for +S9)
 
1)
1) Ishidate MJr (Ed.), Data Book of Mutagenicity Tests on Chemicals in Bacteria, LIC/Japan (1991) (Tables in English)
2) Ministry of Labour, Japan, Mutagenicity Tests of Exist. Chem. Subst., JETOC (Ed.), pp. 165 (1996) (Tables in English)
3)
Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)

œ Ethyl acrylate iƒAƒNƒŠƒ‹Ž_ƒGƒ`ƒ‹ji2-ƒvƒƒyƒ“Ž_ƒGƒ`ƒ‹F@ƒGƒgƒLƒVƒJƒ‹ƒ{ƒjƒ‹ƒGƒ`ƒŒƒ“j@
@@
140-88-5@Industry @ 100.12
AM Sal. Max (?)
 
1,2)
AM Sal. Max ( 2.0 mg/plate, }S9)   3)
MLA L5178Y Min ( 0.2 mg/ml, +S9) › 4)
SM CHO Max ( 0.08  mg/ml, -S9)   5)
CA CHL/IU Min ( 0.01 mg/ml, -S9), 24, 48h @D20= 0.01; TR= 3200

6)
CA CHO Min ( 0.2 mg/ml, +S9), › 7)
CA CHO Min ( 0.2 mg/ml, +S9),   5)
SCE CHO Min ( 018mg/ml, +S9), ›v 7)
DNA L5178Y Max ( 0.03  mg/ml, -S9)   8)
YM S. cerevisiae Min ( 0.73 mg/ml, -S9), › 9)
CT BALB/c-3T3 Min ( 0.012 mg/ml, -S9), › 10)
SLRL Drosophila Max ( 40000 ppm )
 
11)
MNv Mice, BM Min ( 900 mg/kg x 2, ip )
›
12)
MNv Mice, BM Max ( 812 mg/kg x 2, ip )   13, 14)
MNv Mice, spleen Max ( 1.0 g/kg , ip )   15)
SCEv Mice, spleen Max ( 1.0 g/kg , ip )   15)
DNAv Rats, forestomach Max (?)or   16)
DNAv Rats, liver Max ( 0.4 g/kg ), or   17)
‚Pj‚g‚‚—‚‚’‚”‚ˆ S., et al.:Environ. Mutagen., 5 (Supp. 1), 3-142 (1983)
2) Zeiger E., et al.: Environ. Mol. Mutagen, 19, (Suppl. 21). 2-141 (1992)
3) Waegemackers TH & Bensink MP., Mutation Res., 137, 95-102 (1984)
4) McGregor DB., et al., Environ. Mol. Mutagen., 12, 85-154 (1988)
5) Moore MM., et al., Mutagenesis, 6, 77-85 (1991)
6) Ishidate MJr., (ed.) Data Book of Chromosomal Aberration Tests In Vitro, LIC/ Tokyo, Elsevier/the Netherland (1988);
  Sofuni T (Ed.) Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)
7) Loveday KS., et al., Environ. Mol. Mutagen., 16 , 272-303 (1990)
8) Ciaccio PJ., et al., Toxicol. Sci., 46, 324-332
9) Zimmermann FK & Mohr A., Mutation Res., 270, 151-166 (1992)
10) Matthews EJ., et al., Environ. Health Perspect., 101, Suppl., 2, 347-482 (1993)
11) Valencia R., et al.: Envirn. Mutagen., 7, 325-348 (1985)
12) Perybojewska B., et al., Mutation Res., 135, 189-191 (1984)
13) Ashby J. et al., Mutagenesis, 4, 283-285 (1989)
14) Hara T., et al., Mutation Res., Commun., 16, 211-215 (1994)
15) Kligerman AD., et al., Mutagenesis, 6, 137-141 (1991)
16) Morimoto K., et al., Carcinogenesis, 12, 703-708 (1991)
17) Ghanayem BI., et al.: Fund. Appl. Toxicol., 9, 389-391 (1987)

US-NTP Genotoxicity ScreeningF
› Ames TestF@
›w
› MLA TestF@›
› SCE Test with CHO Cells:F@›w
› CA Test with CHO CellsF@›
› SLRL Test with DrosophilaF@ 
@@ @@@

IARC Carcinogenicity criteriaF@
@
Group B2 iProbable human carcinogenj
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œAbbreviation @iΘ—ͺ‹L†j@
œMutagenicity Testing@i•ΟˆΩŒ΄«ŽŽŒ±j
œTest Systems@(ŽŽŒ±–@‚ΜŽν—ށj
œTechnical Problems@i‹Zp“I–β‘θ“_j
œList of@Compoundsi‰»‡•¨ƒŠƒXƒgj
œEvaluation of Results@iŽŽŒ±Œ‹‰Κ‚Μ•]‰Ώj