Group G-4

Group G-4 化学構造　(Chemical Structure)

● Grape pigment （ブドウ色素）
　　　　Food/Natural

AM Sal 　(±S9) ○ 1)

CA CHL/IU Max ( 8.0 mg/ml, -S9), 24, 48h　(No data for +S9) □ 2)

1) Ishidate MJr (Ed.), Data Book of Mutagenicity Tests on Chemicals in Bacteria, LIC/Tokyo (1991) (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)

● Grape skin colour (Oenin) （ブドウ果皮色素）
　　　Food/Natural

AM Sal Max ( 10.0 mg/plate, ±S9) □ 1)

CA CHL/IU Min ( 1.5 mg/ml, -S9), 24h　D20=　3.6; TR=　5.3
(No data for +S9) ○ 2)

MNv Mice Max (1.25 mg/kg, ip, 24h) □ 3)

1) Ishidate MJr (Ed.), Data Book of Mutagenicity Tests on Chemicals in Bacteria, LIC/Tokyo (1991) (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)
3) Hachiya N et al., Toxicol. Forum, 8, 91-105 (1985)

● Grape skin extract （ブドウ果皮抽出物）
　　　　Food/Natural

CA CHL/IU Max ( 5.0 mg/ml, -S9), 24, 48h □ 1)

1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)

● Griseofulvin
126-07-8 　　Fungicide, drug 352.77

AM Sal Max ( 0.4 mg/plate, ±S9) □ 1)

MY Yeast Max ( 0.1 mg/plate), □ 2)

CA Hum. Ly. Min ( 0.04 mg/ml); Poly. ○ 3)

SPAv Mice Min ( 750 mg/kg x 5, ip) ○ 4)

MNv Mice (ICR) Max ( 2.0 g/kg x 3 ) po, 24h □ 5)

1) Wehner FC., et al., Mutation Res., 58, 193-203 (1978)
2) Kuczuk MH., et al., Mutation Res., 53, 11-20 (1978)
3) Larizza L. et al., Mutation Res., 25, 123-130 (1974)
4) Wyrobek AJ & Bruce WR, Natl Acad. Sci.,(USA), 72, 4425-4429 (1975)
5) Morita, T., et al., Mutation Res., 389, 3-122 (1997)

● Guaiac resin （グアヤク脂）
　　 9000-29-7 　　Food　

AM Sal Max ( 5.0 mg/plate, ±S9) □ 1)

CA CHL/IU Max ( 0.16 mg/ml, +S9）,　6-18h □ 2)

1) Fujita H., et al., Ann. Rep. Tokyo Metr. Res. Lab. P.H., 39, 343-350 (1988) (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)

● Guanidine carbonate　（炭酸グアニジン）
　　 593-08-9　Laboratory 　 180.17

CA CHL/IU Max ( 0.50 mg/ml, -S9), 24, 48h　(No data for +S9) □ 1)

1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)

● Guanidine-HCl （塩酸グアニジン）
　　　 50-01-1　　Laboratory 　 95.53

AM Sal/E. coli Max ( 5.0 mg/plate, ±S9) □ 1)

CA CHL/IU Max ( 0.5 mg/ml, -S9), 24, 48h (No data for +S9) □ 2)

1) Ministry of Labor, Japan, Mutagenicity Test Data of Exist. Chemi. Subst., JETOC (Ed.), pp. 166 (1996) (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)

● Guanidine nitrate （硝酸グアニジン）
　　506-93-4　Laboratory 　 122.08　

CA CHL/IU Max ( 0.5 mg/ml, -S9）, 24, 48h (No data for +S9) □ 1)

1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)

● Guanidine phosphate　（燐酸グアニジン）
　　　1763-07-1　　　　Laboratory 　MW: 157.07

CA CHL/IU Max ( 0.46 mg/ml, -S9）, 24, 48h　(No data for +S9) □ 1)

1)　Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)

● Guarana extract （グアラナ抽出物）
　　　　　　　　Food

CA CHL/IU Max ( 5.0 mg/ml, ±S9）, 6-18h □ 1)

1)　Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)

●Top Page　（トップページ）

●Abbreviation 　（省略記号）　

●Mutagenicity 　（変異原性）

●Test Systems　(試験法の種類）

●Technical Problems　（技術的問題点）

●List of　Compounds（化合物リスト）

●Evaluation of Results　（試験結果の評価）

AM	Sal	(±S9)	○	1)
CA	CHL/IU	Max ( 8.0 mg/ml, -S9), 24, 48h　(No data for +S9)	□	2)

AM	Sal	Max ( 10.0 mg/plate, ±S9)	□	1)
CA	CHL/IU	Min ( 1.5 mg/ml, -S9), 24h　D20=　3.6; TR=　5.3 (No data for +S9)	○	2)
MNv	Mice	Max (1.25 mg/kg, ip, 24h)	□	3)

AM	Sal	Max ( 0.4 mg/plate, ±S9)	□	1)
MY	Yeast	Max ( 0.1 mg/plate),	□	2)
CA	Hum. Ly.	Min ( 0.04 mg/ml); Poly.	○	3)
SPAv	Mice	Min ( 750 mg/kg x 5, ip)	○	4)
MNv	Mice (ICR)	Max ( 2.0 g/kg x 3 ) po, 24h	□	5)

AM	Sal	Max ( 5.0 mg/plate, ±S9)	□	1)
CA	CHL/IU	Max ( 0.16 mg/ml, +S9）,　6-18h	□	2)

AM	Sal/E. coli	Max ( 5.0 mg/plate, ±S9)	□	1)
CA	CHL/IU	Max ( 0.5 mg/ml, -S9), 24, 48h (No data for +S9)	□	2)