@@@@@@@@@@@@@@@@@@@@@@@@@@@@@
Group I-1 ‰»Šw\‘’@(Chemical Structure)  

œ Imipramine-HCl@iƒCƒ~ƒvƒ‰ƒ~ƒ“‰–Ž_‰–j
@
@ CASF113-52-0@ Medicine@MW: 316.87
AM Sal. Max (?)
 
1)
CA CHL/IU Max ( 0.02 mg/ml, -S9), 24, 48h@(No data for +S9)
 
2)
DL Mice Max (?)   3)
1) Natl. Inst. Hygien. Sci., Tokyo, (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)
3) Sykora I et al., Mutation Res., 66, 291-299 (1979)

œ Indium chloride
i‰–‰»ƒCƒ“ƒWƒEƒ€j
@
@ 10025-82-8@ Medicine@ 221.8
AM Sal. Max ( 50 ƒΚCi/plate, }S9)
 
1)
1) Ishidate MJr (Ed): Data Book for Mutagenicity Tests on Chemicals in Bacteria, LIC/Tokyo (1991) (Tables in English)

œ Indomethacin iƒCƒ“ƒhƒƒ^ƒVƒ“j

@
@ 53-86-1@ Medicine@ 357.79
AM Sal. Max (?)
 
1)
CA CHL/IU Max ( 0.25 mg/ml, -S9), 24, 48h@(No data for +S9)
 
2)
MNv Mice Max (?)
 
3)
1) Natl. Inst. Hygien. Sci., Tokyo ?
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)
3) Natl. Inst. Hygien. Sci., Tokyo, (?)

œ Instant coffee (freeze dried)
iƒCƒ“ƒXƒ^ƒ“ƒg ƒR[ƒq[j
@@
Food/Natural
CA CHL/IU Min ( 0.5 mg/ml, -S9), 24, 48h@(No data for +S9)G
D
20=0.63; TR=40
›
1)
1) Natl. Inst. Hygien. Sci., Tokyo, (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998)

œ Instant tea (freeze dried) @iƒCƒ“ƒXƒ^ƒ“ƒgg’ƒj
@@@
Food/Natural
CA CHL/IU Min ( 0.25 mg/ml, -S9), 24, 48h(No data for +S9)G
D
20=0.28; TR=60
›
1)
1) Natl. Inst. Hygien. Sci., Tokyo, (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998)  (Tables in English)

œ Iodoform
@iƒˆ[ƒhƒzƒ‹ƒ€j
@@@@
75-47-8 @Veterinary medicine @ 393.78

US-NTP Genotoxicity Screening:
›Ames Test:
 
›CA Test with CHO: 
›SCE Test with CHO:
›W

œ Iron and sodium succinatocitrate
@@@@
@Food @
AM Sal. Max ( 5.0 mg/plate, S9)
 
1)
CA CHL/IU Min( 2.0 mg/ml, -S9), 24h@(No data for +S9):D20= 2.6; TR= 7.2
›w
2)
1) Ishidate MJr (Ed): Data Book for Mutagenicity Tests on Chemicals in Bacteria, LIC/Tokyo (1991)  (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC/Tokyo (1998)  (Tables in English)

œ Iron salt (soluble)@(FeCl3)@i‰–‰»“S(III)j
@@@@
7705-08-0 @Industry @ 162.21

US-NTP Genotoxicity Screening
:
@›MLA:
 

œ Iron sesquioxide iŽOŽ_‰»“ρ“Sj(Feric oxide)
@@@@
11309-37-1@Food@ 159.69
AM Sal. Max ( 50.0 mg/plate, }S9)
 
1)
CA CHL/IU Max ( 0.125 mg/ml, -S9), 24, 48h@(No data for +S9)G@
 
2)
CT SH/embryo Max (?)   3)
1) Ishidate MJr (Ed): Data Book for Mutagenicity Tests on Chemicals in Bacteria, LIC/Tokyo (1991) (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC/Tokyo (1998) (Tables in English)
3) DiPaola JA & Casto BC: Cancer Res., 39, 1008-1013 (1979)
yNotez (Cited from IARC Monographs, Suppl.., 6 (1987)
No data were available on the genetic and related effects of this gent in humans.
It did not induce transformation of Syrian hamster embryo cells. @@(IARC Monographs, 1, 29)

œ Isoamyl acetate@iƒCƒ\ƒAƒ~ƒ‹ƒAƒZƒe[ƒgj
@@
123.92-2@Food/Solvent 130.18
AM Sal. Max ( 10.0 mg/plate, }S9)
 
1)
CA CHL/IU Max ( 2.0 mg/ml, -S9), 24, 48h@(No data for +S9)G@
 
2)
1) Ishidate MJr (Ed): Data Book for Mutagenicity Tests on Chemicals  in Bacteria, LIC/Tokyo (1991)  (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC/Tokyo (1998)  (Tables in English)

US-NTP Genotoxicity Screening:
›Ames Test:
 
› SLRL Test in Drosophila:  

œ Isoamyl butyrate @iƒCƒ\ƒAƒ~ƒ‹ƒuƒ`ƒŒ[ƒgj
@@@
106-27-4@@@Food@@@ 158.24
AM Sal. Max ( 10.0 mg/plate, }S9)
 
1)
CA CHL/IU Min ( 0.5 mg/ml, -S9), 24, 48h@(No data for +S9)
 
2)
1) Ishidate MJr (Ed): Data Book for Mutagenicity Tests on Chemicals in Bacteria, LIC/Tokyo (1991) (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC/Tokyo (1998) (Tables in English)

œ Isoamyl formate i‹aŽ_ƒCƒ\ƒAƒ~ƒ‹j

@@@
110-45-2@@@Food@@@ 116.16
AM Sal. Max ( 10.0 mg/plate, }S9)
 
1)
CA CHL/IU Min ( 2.0 mg/ml, -S9), 24, 48h (No data for +S9)
 
2)
1) Ishidate MJr (Ed): Data Book for Mutagenicity Tests on Chemicals in Bacteria, LIC/Tokyo (1991) (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC/Tokyo (1998) (Tables in English)

œTop Page@iƒgƒbƒvƒy[ƒWj
œAbbreviation @iΘ—ͺ‹L†j@
œMutagenicity @i•ΟˆΩŒ΄«j
œTest Systems@(ŽŽŒ±–@‚ΜŽν—ށj
œTechnical Problems@i‹Zp“I–β‘θ“_j
œList of@Compoundsi‰»‡•¨ƒŠƒXƒgj
œEvaluation of Results@iŽŽŒ±Œ‹‰Κ‚Μ•]‰Ώj